background and aims: diabetic nephropathy (dn) is the most common cause of end-stage renal failure which could increase the risk of cardiovascular disease and morbidity and mortality in patients. the aim of this study was to investigate new modalities for treatment of diabetic nephropathy. methods:this study was a mini-review research to investigate drugs that are used for dn treatment. results...

conclusions spironolactone combined with aceis or arbs leads to reduction of proteinuria in chronic kidney disease and therefore reduction of progression of the disease. objectives the study was designed to assess the effects of spironolactone as the aldosterone antagonist combined with acei or arb drugs to reduce proteinuria in chronic kidney disease to prevent its progression. patients and me...

background: central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. our previous work showed that inhibition of angiotensin converting enzyme (ace) activity prior to induction of ischemia protected the brain from severe ischemia/reperfusion (i/r) injuries. this study evaluated the impacts of post-ischemic inhibition of ace, enalapril, on brain inf...

objective(s): hyperglycemia, oxidative stress and apoptosis have key roles in pathogenesis of diabetic neuropathy. there are local renin-angiotensin systems (rass) in different tissues such as neural tissue. local rass are involved in physiological and pathophysiological processes such as inflammation, proliferation and apoptosis. this study aimed to investigate the role of local renin-angioten...

stroke is the leading cause of death and disability in the world after the cancer and cardiovascular diseases. genetic factors have main significance to got stroke. renin-angiotensin system contains candidate genes and polymorphisms for causing stroke. there are reported associations between stroke and angiotensin ii type-1 receptor g. 1166a > c polymorphism (rs5186). therefore in this study th...

Background and aims: Diabetic nephropathy (DN) is the most common cause of end-stage renal failure which could increase the risk of cardiovascular disease and morbidity and mortality in patients. The aim of this study was to investigate new modalities for treatment of diabetic nephropathy. Methods:This study was a mini-review research to investigate drugs that are used for DN treatment. Resul...

The important renal endocrine aspect implicated in gym nephropathy is the activation of renin-angiotensin-aldosterone system (RAAS). Intense exercise can lead to increased sympathetic nervous activity, resulting release renin from juxtaglomerular cells kidneys. Renin acts on angiotensinogen, leading generation angiotensin II, a potent vasoconstrictor. Angiotensin II stimulates secretion aldoste...

buckwheat rutin has been found to be able to inhibit angiotensin ii (angii) - induced hypertrophy in cultured neonatal rat cardiomyocytes, but the mechanism remains uncertain. in this study, myocardial hypertrophy model was made by adding angii to the medium of cardiac myocytes of neonatal rats, meanwhile, different concentrations of buckwheat rutin were applied to observe their effects. intrac...