the human leukocyte antigen-b27 is one of the class i molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (as) . the strength of the disease association with b27 varies markedly among racial and ethnic populations. it is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distributi...

background: hla-b*27 is strongly associated with ankylosing spondylitis (as). it represents a family of alleles that differ among ethnic groups. objective: the aim of this study was to determine the distribution of hla-b*27 alleles in as patients and healthy controls in isfahan (iran). methods: sixty as patients and 430 healthy blood donors were selected. all subjects were hla-b*27 positive by ...

We compared the incidence, nature and frequency of chest pain in a group of 45 ankylosing spondylitis patients with an age and sex matched group of normals. Twenty-five ankylosing spondylitis patients had experienced recurrent chest pain compared to three normals, and had a significantly reduced chest expansion. The presence of chest pain in ankylosing spondylitis can be an early presenting fea...

BACKGROUND Vitamin D is a steroid hormone that plays essential roles in calcium and phosphorus metabolism, bone formation and mineralization homeostasis, also has a role in the maintenance of immune-homeostasis. OBJECTIVE We aimed to investigate seasonal serum vitamin D levels and seasonal disease activity in patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Osteoarthritis. ME...

Ankylosing spondylitis is a chronic inflammatory rheumatic disease, which is characterized by inflammation of the spine and the sacroiliac joints. To date, the disease etiology remains unclear. In the present study, the correlation of T lymphocyte subset changes with the progression of ankylosing spondylitis was investigated. A total of 55 patients with ankylosing spondylitis (22 severe and 23 ...

Common polymorphisms of microRNA gene MIR146A were reported as associated with different autoimmune diseases, include systemic lupus erythematosus, psoriatic arthritis, asthma and ankylosing spondylitis. In this study we investigated MIR146A SNPs in Chinese people with ankylosing spondylitis. Three common SNPs: rs2910164, rs2431697 and rs57095329 were selected and genotyped in 611 patients and ...

We have found increased small intestinal permeability to 51Cr-ethylenediaminetetra acetate in patients with ankylosing spondylitis compared with controls. There is no significant difference between patients with ankylosing spondylitis and patients with rheumatoid arthritis taking non-steroidal anti-inflammatory drugs (NSAID). The increased intestinal permeability in ankylosing spondylitis is in...

it has been demonstrated that natural killer (nk) cells play a role in regulation of autoimmunity. they play a protective role in several rodent disease models. in this study we aimed to compare the immunophenotypic features of nk cells in ankylosing spondylitis (as) with normal subjects with regard to cd56 and cd16 molecules. this study was carried out on 30 as patients and 33 normal volunteer...

AIM To evaluate the relationship between mental and physical health in Chinese patients with ankylosing spondylitis (AS) and to identify the predictors of psychological status. METHODS Patients with AS (n=103) and healthy controls (n=121) were surveyed between 2010 and 2011 (cross-sectional study). The Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional ...

INTRODUCTION Few studies have assessed the prevalence and features of axial spondyloarthritis (axSpA) and ankylosing spondylitis in diverse, population-based, community settings. OBJECTIVES We used computerized diagnoses to estimate the prevalence of axSpA and ankylosing spondylitis in Kaiser Permanente Northern California (KPNC). METHODS We identified persons aged 18 years or older with 1 ...