نتایج جستجو برای: anp

تعداد نتایج: 4314  

Journal: :Thorax 1996
R M Angus E A Millar G W Chalmers N C Thomson

BACKGROUND The hormone atrial natriuretic peptide (ANP) causes bronchodilation and partially protects against direct and indirect bronchial challenges. Both in vitro and in vivo studies have found that the protective effect of ANP against bronchoconstriction is enhanced by inhibition of the enzyme neutral endopeptidase (NEP). It was hypothesised that pretreatment with thiorphan, an NEP inhibito...

2010
Paul M. McKie Alessandro Cataliotti Guido Boerrigter Horng H. Chen S. Jeson Sangaralingham Fernando L. Martin Tomoko Ichiki John C. Burnett

M-atrial natriuretic peptide (ANP; M-ANP) is a novel next generation 40 amino acid peptide based on ANP, which is highly resistant to enzymatic degradation and has greater and more sustained beneficial actions compared with ANP. The current study was designed to advance our understanding of the therapeutic potential of M-ANP in a canine model of acute angiotensin II–induced hypertension with el...

Journal: :Hypertension 2010
Paul M McKie Alessandro Cataliotti Guido Boerrigter Horng H Chen S Jeson Sangaralingham Fernando L Martin Tomoko Ichiki John C Burnett

M-atrial natriuretic peptide (ANP; M-ANP) is a novel next generation 40 amino acid peptide based on ANP, which is highly resistant to enzymatic degradation and has greater and more sustained beneficial actions compared with ANP. The current study was designed to advance our understanding of the therapeutic potential of M-ANP in a canine model of acute angiotensin II-induced hypertension with el...

Journal: :Circulation research 1989
H Ruskoaho O Vakkuri O Arjamaa O Vuolteenaho J Leppäluoto

Atrial wall stretching is a known stimulus for atrial natriuretic peptide (ANP) secretion. The effects of the stimulation of autonomic nervous system, hemodynamic factors, and humoral factors (epinephrine, angiotensin, vasopressin, and brain extracts) on the release of ANP under basal conditions and during increased atrial pressure produced by acute volume loading in pithed rats were examined. ...

Journal: :Hypertension 1991
Y Hirata H Matsuoka H Hayakawa T Sugimoto E Suzuki K Kangawa H Matsuo

To explore whether pathophysiological plasma levels of atrial natriuretic peptide (ANP) actually involve sodium excretion in spontaneously hypertensive rats (SHR), we examined the in vivo and ex vivo effects of ANP and an endopeptidase inhibitor, thiorphan, on urinary sodium excretion and the elimination rate of ANP. We found the following: 1) The basal plasma ANP level was higher in 16-week-ol...

Journal: :The American journal of physiology 1998
Robin Donna Deliva Uwe Ackermann

Atrial natriuretic peptide (ANP) inhibits renal sympathetic nerve activity (RSNA), provided the vagi are intact. Afferents from chemosensitive cardiopulmonary receptors are specifically required. Such receptors produce the Bezold-Jarisch reflex, are prominent on the ventricular epicardium, and are richly supplied with 5-hydroxytryptamine type 3 (5-HT3) receptors. We tested the hypothesis that e...

Journal: :Peptides 2004
Zhengrong Wang Liguo Chen Chaomin Wan Yi Qu G Cornélissen F Halberg

A new insofar as chronobiologic therapeutic approach by atrial natriuretic peptide (ANP) for hypertension and/or congestive heart failure (CHF) is based on the release of ANP from ANP cDNA transfected Chinese Hamster Ovary (CHO) cells encapsulated in polycaprolactone (PCL) tubes. ANP secretion was maintained for at least 6 months. The encapsulated cells remained viable during culturing. Control...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2010
Kuichang Yuan Jiahua Yu Amin Shah Shan Gao Sun Young Kim Sung Zoo Kim Byung-Hyun Park Suhn Hee Kim

Leptin is a circulating adipocyte-derived hormone that influences blood pressure (BP) and metabolism. This study was designed to define the possible role of leptin in regulation of the atrial natriuretic peptide (ANP) system using acute and chronic experiments. Intravenous infusion of rat leptin (250 microg/kg injection plus 2 microg.kg(-1).min(-1) for 20 min) into Sprague-Dawley rats increased...

2015
Noriyuki Ogawa Hiroshi Komura Kenji Kuwasako Kazuo Kitamura Johji Kato

BACKGROUND Plasma levels of atrial and brain natriuretic peptides (ANP and BNP) are increased in patients with chronic kidney disease (CKD) complicated with deteriorated kidney function, but the relationship between the plasma level of ANP or BNP and the future development of CKD is unclear. METHODS We measured the plasma ANP and BNP levels of 294 local residents without CKD in a Japanese com...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2004
Alexandra K Kiemer Anke C Förnges Kostas Pantopoulos Manfred Bilzer Bill Andriopoulos Tobias Gerwig Silke Kenngott Alexander L Gerbes Angelika M Vollmar

Atrial natriuretic peptide (ANP)-preconditioned livers are protected from ischemia-reperfusion injury. ANP-treated organs show increased expression of heme oxygenase (HO)-1. Because HO-1 liberates bound iron, the aim of our study was to determine whether ANP affects iron regulatory protein (IRP) activity and, thus, the levels of ferritin. Rat livers were perfused with Krebs-Henseleit buffer [+/...

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