for diaCEST agents; b) CEST contrast curves for representative salicylic acid (1) and anthranilic acid derivatives (2, 4, 11 and 12) using B1 = 3.6 μT, tsat = 3 s (25 mM , pH 7.1-7.4). Anthranilic Acid Analogues as Uncommonly Shifted HYdrogen bonded (U SHY) diamagnetic CEST (diaCEST) MRI Contrast Agents based on the N-H exchange Xiaolei Song, Xing Yang, Sangeeta Ray Banerjee, Martin G Pomper, a...

HE tryptophan-I ( t r yp I ) locus is located in linkage group I11 in Neurospora crassa. TATUM and BONNER (1944) and BEADLE and TATUM (1945) reported tryp-I mutant 10575, which could utilise either indole or tryptophan. AHMAD and CATCHESIDE (1960) brought forward evidence that a new group of five anthranilic acid mutants were allelic to 10575. The present paper describes complementation studies...

Attempts to develop a desirable reduced fat Cheddar cheese are impeded by a propensity for flavor defects such as meaty-brothy, putrid, fecal, and unclean off-flavors in these products. Recent studies suggest aromatic amino acid catabolism of starter, adjunct, and nonstarter lactic acid bacteria significantly impact off-flavor development. The objective of this study was to delineate pathways f...

To quantify the full range of tryptophan metabolites along the kynurenine pathway, a liquid chromatography - tandem mass spectrometry method was developed and used to analyse brain extracts of rodents treated with the kynurenine-3-mono-oxygenase (KMO) inhibitor Ro61-8048 during pregnancy. There were significant increases in the levels of kynurenine, kynurenic acid, anthranilic acid and 3-hydrox...

The first total syntheses of cyclopeptides versicotide E and F, containing anthranilic acid, are reported. Evaluation the herbicide activity, cyanobacteria inhibition microcystins concentration all versicotides A?F demonstrated that several them could be considered as lead candidates in development bioherbicides to mitigate environmental impact evolution agriculture has had on water quality.

Kotake and Nakayama (1) observed the conversion of kynurenine to anthranilic acid and alanine by a mammalian liver extract. Subsequently the enzyme responsible for this reaction in the mammal was partly purified (2,3) and the enzyme, prepared from vitamin Be-deficient animals, was shown to require pyridoxal phosphate for its maximal activity (2). During an investigation of tryptophan metabolism...

Small-molecule fluorescent reporters of disease states are highly sought after, yet they remain elusive. Anthranilic acids are extremely sensitive environmental probes, and hold promise as general but selective agents for cancer-cell detection if they can be equipped with the appropriate targeting groups. The optical properties of a small library of N-isopropyl invariant anthranilic acids were ...