Objective To investigate the effects of anti-epileptic drugs (AED) on overall burden disease in patients with neuro-autoimmune (NAD). Background AEDs have shown to provide benefits against neurological damage various illnesses. However, extent role neuroprotection and prevention additional comorbidity NAD has not been completely characterized. Design/Methods A retrospective analysis 34464 hospi...

BACKGROUND One third of epileptic patients are resistant to several anti-epileptic drugs (AED). P-glycoprotein (P-gp) is an efflux transporter encoded by ATP-binding cassette subfamily B member 1 (ABCB1) gene that excludes drugs from the cells and plays a significant role in AEDs resistance. Over-expression of P-gp could be a result of polymorphisms in ABCB1 gene. We studied the association of ...

objective the ketogenic diet is a high-fat, low carbohydrate, adequate protein diet,developed in the 1920s for the management of intractable seizure disorders in children. to evaluate efficacy and tolerability of the classic  ketogenic diet, we analyzed records of the children started on the diet from 1999 to 2006 at the mofid children's hospital.materials & methods   the subjects were 87 child...

Epilepsy is one of the most common neurologic disorders in dogs and life-long treatment with antiepileptic drugs (AED) is frequently required. Adverse events of AED targeting the skin are only rarely reported in veterinary medicine and the true incidence and spectrum of cutaneous reactions in epileptic dogs remains unknown. In this study, we hypothesized that cutaneous reactions commonly occur ...

Aim: To examine the effects of anti-epileptic drugs (AED) used during pregnancy on the frequency and the type of congenital malformations in newborns. Methods: The study included 96 newborns, born by mothers affected by epilepsy (before the pregnancy). The control group consisted of 96 healthy newborns delivered by mothers. Results: Almost all of the pregnant women used AED (98%) during the pre...

Ribeirão Preto School of Medicine, University of São Paulo, São Paulo SP, Brazil: Physician Resident in Neurology, Department of Neurosciences and Behaviour Sciences; Neurologist and Associated Professor, Department of Neurosciences and Behaviour Sciences; Emergencist Physician, Departament of Internal Medicine. Idiosyncratic reactions to drugs are adverse effects not straightly related with ph...

OBJECTIVE Some anti-epileptic drugs (AED) have well-known teratogenic effects. The aim of the present study was to elucidate the effect of prenatal exposure to AED and the risk of enamel defects in the primary and permanent dentition. METHODS A total of 38 exposed and 129 non-exposed children, 6-10 years of age, were recruited from the Aarhus Birth Cohort and the Department of Neurology, Vibo...

A major challenge in experimental epilepsy research is to reconcile the effects of anti-epileptic drugs (AEDs) on individual neurons with their network-level actions. Highlighting this difficulty, it is unclear why carbamazepine (CBZ), a frontline AED with a known molecular mechanism, has been reported to increase epileptiform activity in several clinical and experimental studies. We confirmed ...

Adverse effects of anti-seizure/anti-epileptic medications on bone density have been observed and reported since the early 1960s. Phenytoin and carbamazepine are two commonly prescribed anti-epileptic drugs most frequently associated with osteomalacia including fractures, bone demineralization, and reduced bone formation. The mechanism by which anti-epileptic drugs induce bone loss is not fully...