1 Centre National de Référence des Francisella, Institut de Biologie et Pathologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France 2 Laboratoire Adaptation et Pathogénie des Microorganismes, Université Joseph Fourier – Grenoble 1, Grenoble, France 3 Laboratoire Adaptation et Pathogénie des Microorganismes, CNRS/UJF, UMR 5163, Grenoble, France *Correspondence: mmaurin@chu-grenobl...

This work demonstrates a design strategy to optimize antimicrobial peptides with an ideal balance of minimal cytotoxicity, enhanced stability, potent cell penetration and effective antimicrobial activity, which hold great promise for the treatment of intracellular microbial infections and potentially systemic anti-infective therapy.

In female body, a vast number of skin changes occur during pregnancy. Some of them are quite distressing to many women. Therefore, performing treatment for physiologic skin changes during pregnancy with antiinfective agents, glucocorticosteroids, topical immunomodulators, retinoids, minoxidil, etc., is discussed. Drug administration during pregnancy must be reasonable.

A simple and straightforward synthetic approach to potential anti-infective thiolactone-isatin hybrids led to the discovery of novel tetracyclic compounds which bear a macrocylic motif containing an unusual bridged amide bond.

Microbial resistance to conventional antibiotics is one of the most outstanding medical and scientific challenges of our times. Despite the recognised need for new anti-infective agents, however, very few new drugs have been brought to the market and to the clinic in the last three decades. This review highlights the properties of a new class of antibiotics, namely dendrimeric peptides. These i...

Treatment strategies for herpes zoster infection include limiting viral replication with anti-infective agents as well as limiting associated acute and chronic neuropathic pain with a variety of analgesics. The author outlines currently available pharmacotherapeutic options, from first-line (eg, anti-infective agents, tricyclic antidepressants, anticonvulsants, opioid analgesics, and topical ag...

THE CONCEPT of intestinal antisepsis is not new. I t was under taken without success in the preceding century. Not unti l 1941,20 with the discovery of succinylsulfathiazole, was a practical intestinal antiseptic available. T h e sulfa drugs are bacteriostatic-not bactericidal--agents. Consequently, they must be administered for a considerable period of t ime and the resident organisms must be ...