Introduction: Feverfew (Tanacetum parthenium) (T.p.) is widely used in folk medicine to treat many diseases. We reported the analgesic effect of T.p. flower and leaf previously. Present study is designed to find the mechanism underlying the anti-nociceptive effect of the aqueous extract of T.p. flower. Method: Based on our previous study, the dose 50 mg/kg i.p. of the T.p. aqueous extract had...

The aim of this study was to assess the in vivo potential of ethanolic extracts of Glycine max (L.) Merr. (SoRiTae) and Rhynchosia nulubilis (Yak-Kong) seeds as natural anti-nociceptive and anti-inflammatory agents. To assess the anti-nociceptive and anti-inflammatory potential, the ethanolic extracts of SoRiTae and Yak-Kong seeds were tested in arachidonic acid-induced ear edema, carrageenan i...

Anti-nociceptive, anti-inflammatory and gastroprotective activities of the known C-glycosyl flavonoid, isoorientin, were studied in rats and mice. For the anti-nociceptive activity assessment the p-benzoquinone-induced writing test, for the anti-inflammatory activity the carrageenan-induced hind paw edema model in mice, and for the gastroprotective activity the EtOH-induced ulcerogenesis model ...

the purpose of the present study was to evaluate anti-nociceptive effects of morphine, tramadol, meloxicam and their combinations in rats. seventy male wistar rats were divided into seven equal groups and randomly assigned to receive intraperitoneal saline (s) (control group, 1.0 ml kg-1), morphine (mo) (4.0 mg kg-1), tramadol (tr) (12.5 mg kg-1), meloxicam (ml) (1.0 mg kg-1), tramadol- morphin...

conclusions our findings suggest that the analgesic effect of hrcle may be mediated via both peripheral and central mechanisms. the presence of flavonoids might be responsible for the anti-nociceptive activity of this plant. results hrcle significantly inhibited the number of contractions induced by acetic acid in the writhing test at all doses, while anti-nociceptive activity was only shown at ...

We measured anti-nociceptive activity of prim-o-glucosylcimifugin (POG), a molecule from Saposhnikovia divaricate (Turcz) Schischk. Anti-nociceptive or anti-inflammatory effects of POG on a formalin-induced tonic nociceptive response and a complete Freund's adjuvant (CFA) inoculation-induced rat arthritis pain model were studied. Single subcutaneous injections of POG produced potent anti-nocice...

objective(s):reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. we investigated tolerance to anti-nociceptive effects of orexin-a, an endogenous potent analgesic peptide using the hot-plate test.materials and methods:orexin-a was microinjected icv (intracerebroventricular) with an interval of 12 hr for 7 continuous days and...

Introduction: Coconut shell liquid smoke (CS-LS) from Cocos nucifera L. has been traditionally used by Indonesians as a natural preservative. Besides that, is also medicine to treat various types of wounds. During the storage, resulting pyrolysis still questionable in relation oxidation process and changes its properties potentials. We observed physical characteristics, components, toxicity, an...