group exhibits an extended antimicrobial spectrum including anti-pseudomonal activity and high stability to renal dehydropeptidase-I (DHP-I)1}. From the structureactivity relationship studies, we found that the basicity of the C-2 side chain is important for exhibiting antimicrobial activity especially against Pseudomonas aeruginosa by supporting good permeability through the outer membrane(OM)...

GR 20263 is a new broad-spectrum injectable cephalosporin which is stable to most beta-lactamases. Its in vitro activities were of the same order as those of cefotaxime against most gram-negative bacteria, were clearly inferior to cefotaxime against Staphylococcus aureus, but were significantly more active against Pseudomonas aeruginosa. Against the 25 strains used, GR 20263 was significantly m...

a new series of transition metal complexes of co(ii), ni(ii), cu(ii) and zn(ii), has beensynthesized from the knoevenagel condensate schiff base ligand(l) derived from β-ketoanilideand furfural with o-phenylenediamine and diethylmalonate. structural features were determinedby spectral and analytical techniques. square-planar geometry has been adopted by thecomplexes except cobalt complex which ...

In chronic respiratory disease, the formation of dense, 3-dimensional "microcolonies" by Pseudomonas aeruginosa within the airway plays an important role in contributing to resistance to treatment. An in vitro biofilm model of pseudomonal microcolony formation using artificial-sputum (AS) medium was established to study the effects of low-molecular-weight alginate oligomers (OligoG CF-5/20) on ...

actinomycetes were isolated from marine sediment samples collected from the east coast of chennai, tamil nadu, india. well diffusion and agar plug methods were used for the evaluation of antibiotic production by these isolates against drug resistant methicillin- resistant staphylococcus aureus (mrsa) and vancomycin resistant enterococci (vre). the potential isolate vitbrk2 was mass cultured for...

Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic infections in the lungs of individuals with cystic fibrosis. It is intrinsically resistant to many antibiotics, and resistance is emerging rapidly to those drugs that currently remain efficacious. Therefore, there is a pressing need to identify new anti-pseudomonal drug targets. To this end, we have characterized the P. aer...

Background—A previous retrospective study suggested that a policy of regular anti-pseudomonal antibiotic treatment improved pulmonary function and increased survival in patients with cystic fibrosis chronically infected with Pseudomonas species. The results of a prospective multicentre study to compare the eVects on pulmonary function and mortality of three monthly elective anti-pseudomonal ant...

Pseudomonas aeruginosa is intrinsically resistant to a variety of antimicrobials and can develop resistance during anti-pseudomonal chemotherapy both of which compromise treatment of infections caused by this organism. Resistance to multiple classes of antimicrobials (multidrug resistance) in particular is increasingly common in P. aeruginosa, with a number of reports of pan-resistant isolates ...