Continuous input of pharmaceuticals into rivers, through wastewater treatment systems, may cause adverse effects on the aquatic ecosystems of the receiving waterbodies, due to the intrinsic biological activity of these compounds. To investigate this issue, we have carried out an Environmental Risk Assessment in the lower part of the Llobregat River basin (NE Spain). The survey was carried out a...

The association between nonsteroidal antiinflammatory drugs (NSAIDs) and upper gastrointestinal complications is well documented. However, epidemiologic data on the risk of clinically symptomatic but uncomplicated peptic ulcer are quite limited. The authors studied the association between prescription NSAIDs and the risk of symptomatic ulcer in a population-based cohort of 458,840 persons and 1...

background: data suggest that v. arctostaphylos, b. thunbergii var. atropurpurea, e. angustifolia and l. acanthodes may prevent gastric ulcers induced by non-steroidal anti-inflammatory drugs (nsaids). objective: to explore the ulcer-protective potential of these plants in indomethacin-induced gastric ulcers in rats. methods: saline, hydro-alcoholic extract of each plant (100, 400, 800 mg/kg) a...

peperomia pellucida leaf extract was characterized for its anticancer, antimicrobial, antioxidant activities, and chemical compositions. anticancer activity of p. pellucida leaf extract was determined through colorimetric mtt (tetrazolium) assay against human breast adenocarcinoma (mcf-7) cell line and the antimicrobial property of the plant extract was revealed by using two-fold broth micro-di...

antibiotic guidelines have proven to be a simple and effective intervention to guide the choice of appropriate empiric antibiotic regimens. the goals of this study were to evaluate adherence to guidelines and streamlining of antibiotics. hospital records of hospitalized patients in infectious diseases ward imam khomeini hospital, tehran, iran, from may 2008 to september 2009 were reviewed. adhe...

background: the expanse of dendritic cells (dc) differentiation plays an important role in determining immune response. dc-based immunosuppressive drugs have notable side effects in increasing the risk of infectious diseases and cancers. g2013, as a novel anti-inflammatory and immunosuppressive agent, has been tested in experimental model of multiple sclerosis. the aim of this study was to cond...

atrial fibrillation (af) is a commonly encountered arrhythmia in our daily practice. every year a huge bulk of data is published about different management strategies, new antiarrhythmic drugs, anticoagulation protocols and ablation procedures in these patients. in this review article, we discuss different management strategies and new antiarrhythmic drugs as well as those commonly used. we wil...

background vitamin d (vit d) level may change variously in serums of patients undergoing anti-tuberculosis (anti-tb) therapy using antibiotics such as isoniazid and rifampin. objectives the current study aimed to evaluate all components of calcium (ca) regulatory agents in the six- month period of standard anti- tb therapy. patients and methods eight adults whose pulmonary tb had been diagnosed...

ba ckground: legionella pneumophila is  a  dangerous pathogenic bacterium can cause serious infectious diseases especially in hospitalized immuno-compromised patients. this bacterium is shown to be resistant against different antibiotics. resistance against a wide range of antibiotics is usually mediated by efflux pump in bacteria. efflux pumps are proteinaceous transporters localized in the cy...

The rapidly declining prevalence of Helicobacter pylori infection and widespread use of potent anti-secretory drugs means peptic ulcer disease has become substantially less prevalent than it was two decades ago. Management has, however, become more challenging than ever because of the threat of increasing antimicrobial resistance worldwide and widespread use of complex anti-thrombotic therapy i...