The cyanoacrylate polymer particles, which do not contain antibiotics or antibacterial agents, bond with the cell wall of drug-resistant bacteria, and then induced an auto-destructive behavior that causes the bacteria to destroy itself. Because of this, the drug-resistant bacteria are unable to arise. One noteworthy point of this nano-polymer is that it excels in safety given its induction of b...

Silver(I)-induced instant gelation of pyridine-containing Fmoc-l-glutamate and its concentration-dependent self-assembly from nanotubes to nanofibers are investigated. The formed metallogel with nanostructure has remarkably enhanced antibacterial activities. Interestingly, the nanotube and nanofiber exhibit different antibacterial activities, and a corresponding antimicrobial mechanism is propo...

Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential protein...