Background and objectives: Recently, deep vein thrombosis (DVT) has remained a major cause of morbidity and death. DVT is a serious public health issue and can be complicated by pulmonary embolism and stroke leading to high economic burden. Disease etiologies may include protein C deficiency, protein S deficiency, factor V Leiden gene mutation, prothrombin gene 20210A mutation,...

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PETERSON, R.D.A., COOPER, M.D. & GOOD, R.A. (1965) The pathogenesis of immunological deficiency disease. Amer. J. Med. 38, 579. RAFSKY, H.A., WEINGERTEN, M., KRIEGLER, C.I., STERN, K.G. & NEWMAN, B. (1950) Electrophoretic studies in liver disease. Gastroenterology, 14, 29. ROSEN, F.S. & JANEWAY, C.A. (1966) The gamma globulins. III. The antibody deficiency syndromes. New Engl. J. 275, 709. SHER...

primary antibody deficiencies are the most frequent primary immunodeficiency disorders. bronchiectasis as a feature of these disorders may be developed due to some factors such α-1-antitrypsin deficiency. in order to determine the prevalence of two common α-1-antitrypsin deficiency alleles (pi*z and pi*s) in iranian patients with antibody deficiency, this study was performed. the prevalence of ...

background : aids is acquired by infection with hiv (human immuno-deficiency virus). it leaves the host susceptible to malignant and unusual infections especially opportunistic ones. most of aids patients infected with opportunistic parasitic infections die because of chronic diarrhea and deaths due to cryptosporidium diarrhea in aids patients are considerable in the recent two decades. the aim...

background: h-reflex is a valuable electrophysiological technique for assessing nerve conduction through entire length of afferent and efferent pathways, especially nerve roots and proximal segments of peripheral nerves. the aim of this study was to investigate the relation between normal values of flexor carpi radialis (fcr) h-reflex latency, upper limb length and age in normal subjects, and t...

background: antiphospholipid antibody syndrome (aps) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (sle). anticardiolipin antibody (acl) of igg and/or igm isotype in blood, measured by a standardized elisa is the most acceptable laboratory criteria. aps igg isotype, particularly igg2 subclass is more strongly associated ...

BACKGROUND Although severe T cell immunodeficiency in DiGeorge anomaly is rare, previous studies of humoral function in these patients have found no antibody abnormalities but have not examined the response to polysaccharide antigens. Isolated cases of autoimmunity have been reported. Several patients with 22q11.2 deletion attending our immunology clinic suffered recurrent sinopulmonary infecti...

Gennery A, Barge D, O’Sullivan J, et al. Arch Dis Child. 2002;86:422–425 Purpose of the Study. The aim of this study was to investigate humoral immunity, particularly antibody response to pneumococcal polysaccharide, and autoimmune anomalies in a cohort of patients with 22q11 deletion. Study Population. Thirty-two patients from the Newcastle, United Kingdom (UK) Pediatric Immunology Clinic were...

neutropenia is characterized by decrease in the absolute number of circulating neutrophils and an increase susceptibility to infections. the current study was performed in order to explain the clinical and laboratory findings of patients with antibody deficiency disorders associated neutropenia. the patients' records of 19 neutropenic cases out of 207 patients with antibody deficiencies, who ha...