نتایج جستجو برای: antibody diversity
تعداد نتایج: 353374 فیلتر نتایج به سال:
Antibody repertoire diversity, potentially as high as 10(11) unique molecules in a single individual, confounds characterization by conventional sequence analyses. In this study, we present a general method for assessing human antibody sequence diversity displayed on phage using massively parallel pyrosequencing, a novel application of Kabat column-labeled profile Hidden Markov Models, and tran...
Genetic diversity of viral isolates in human immunodeficiency virus (HIV)-infected individuals varies substantially. However, it remains unclear whether HIV-related disease progresses more rapidly in patients harboring virus swarms with low or high diversity and, in the same context, whether high or low diversity is required to induce potent humoral and cellular immune responses. To explore whe...
In the use of non-antibody proteins as affinity reagents, diversity has generally been derived from oligonucleotide-encoded random amino acids. Although specific binders of high-affinity have been selected from such libraries, random oligonucleotides often encode stop codons and amino acid combinations that affect protein folding. Recently it has been shown that specific antibody binding loops ...
The identity of patients must be protected when patient data are shared. The two most commonly used models to protect identity of patients are L-diversity and K-anonymity. However, existing work mainly considers data sets with a single sensitive attribute, while patient data often contain multiple sensitive attributes (e.g., diagnosis and treatment). This article shows that although the K-anony...
Antibody libraries are important resources to derive antibodies to be used for a wide range of applications, from structural and functional studies to intracellular protein interference studies to developing new diagnostics and therapeutics. Whatever the goal, the key parameter for an antibody library is its complexity (also known as diversity), i.e. the number of distinct elements in the colle...
BACKGROUND Antibody phage display is a proven key technology that allows the generation of human antibodies for diagnostics and therapy. From naive antibody gene libraries - in theory - antibodies against any target can be selected. Here we describe the design, construction and characterization of an optimized antibody phage display library. RESULTS The naive antibody gene libraries HAL9 and ...
xxiv CHAPTER 1 – INTRODUCTION 1 1.1 Research background 1 1.2 Literature review 2 1.2.1 Immune system 2 1.2.2 Antibody and its classes 3 1.2.3 The structure of antibody 6 1.2.4 Recombinant antibody 7 1.2.5 Diversity of antibody 9 1.2.6 Antibody library 9
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