OBJECTIVE To provide recommendations, policies, and procedures pertaining to the provision of optimized anticoagulation therapy designed to achieve desired clinical endpoints while minimizing the risk of anticoagulant-related adverse outcomes (principally bleeding and thrombosis). STUDY SELECTION AND DATA EXTRACTION Due to this document's scope, the medical literature was searched using a var...

A systematic review and meta-analysis were conducted to evaluate the efficacy and safety of early prophylactic anticoagulation for the prevention of portal vein system thrombosis (PVST) after splenectomy. A systematic search of the PubMed, EMBASE, Springer and Cochrane Library databases was performed to identify studies comparing the outcomes in patients receiving or not receiving regular proph...

BACKGROUND Anticoagulation is an essential lifesaving management practice indicated for arterial, venous and intracardiac thromboembolism. AIM This study was undertaken to examine the utilization of anticoagulation services in University of Nigeria Teaching Hospital, Enugu (UNTH) Nigeria. MATERIALS AND METHODS This retrospective study involved assessing data from folders of subjects on anti...

BACKGROUND The complexity of anticoagulation therapy requires a patient's command of anticoagulation-related knowledge to assist in maintaining optimal therapy and reducing adverse events. Verbal evaluations may overestimate the patient's comprehension of anticoagulation knowledge. OBJECTIVES This first phase study developed and pilot tested the Anticoagulation Knowledge Assessment (AKA) inst...

The title suggests that anticoagulation may no longer have a role in the treatment of atherothrombotic cerebrovascular disease. While evidence from recent studies has not shown a distinct benefit of anticoagulation following acute stroke, the designs of these studies may not have distinguished important differences in stroke types adequately. Before judging anticoagulation, we will review the p...

The title suggests that anticoagulation may no longer have a role in the treatment of atherothrombotic cerebrovascular disease. While evidence from recent studies has not shown a distinct benefit of anticoagulation following acute stroke, the designs of these studies may not have distinguished important differences in stroke types adequately. Before judging anticoagulation, we will review the p...

Anticoagulation is required during continuous renal replacement therapy to prevent filter clotting and optimize filter performance. However, anticoagulation may also be associated with serious bleeding complications. Patients with liver failure often suffer from underlying coagulopathy and are especially prone to anticoagulation complications. The aim of this review is to present the unique fea...

Anticoagulation is indicated in most cardioembolic ischemic strokes for secondary prevention. In many cardiac conditions, anticoagulation is also indication for primary stroke prevention, mainly when associated to vascular risk factors. Anticoagulation should be started as soon as possible, as it is safe even in moderate acute strokes. The efficacy of early anticoagulation after cardioembolic s...