The study of metabolites from a new strain of Aspergillus tamarii evolved from our interest in fungi as a source of biologically active compounds. An interesting spectrum of antifungal activity exhibited by broth cultures of this organism led to the isolation of a metabolite, A30641, showing in vitro activity against fungi and Gram-positive bacteria. In addition to this new substance, a previou...

In a selective screening for antifungal metabolites, six new clavam antibiotics, clavamycins A, B, C, D, E and F, have been detected from two variants of Streptomyces hygroscopicus NRRL 15846 and NRRL 15879.

The antifungal activity of isolated lactic acid bacteria (LAB) from a locally fermented cereal, "Kunu", was tested against toxigenic Aspergillus flavus. The liquid refreshment, "Kunu", was prepared under hygienic condition using millet, sorghum, and the combination of the two grains. The antifungal potential of isolated LAB against toxigenic A. flavus was carried out using both in vitro and in ...

Actinobacteria is found to have a potent metabolic activity against pathogens. The present study reveals the assessment of potent antifungal secondary metabolites from actinobacteria isolated from Indian marine mangrove sediments. The samples were collected from the coastal regions of Muthupet, Andaman and the Nicobar Islands. Identification was carried out using 16S rRNA analysis and biosynthe...

Objective (s): The green synthesis of copper nanoparticles using metabolites of microorganisms has gained much interest in recent years. In this work, it was studied optimization of copper nanoparticles synthesis using E. coli and its antifungal activity.Materials and Methods: The copper nanoparticles were synthesized by Escherichia coli. Effect of copper nitrate concentration and temperature w...

Many metabolites with novel structures and biological activities have been isolated from the mangrove fungi in the South China Sea, such as anthracenediones, xyloketals, sesquiterpenoids, chromones, lactones, coumarins and isocoumarin derivatives, xanthones, and peroxides. Some compounds have anticancer, antibacterial, antifungal and antiviral properties, but the biosynthesis of these compounds...

Metabolomics and genomics are two complementary platforms for analyzing an organism as they provide information on the phenotype and genotype, respectively. These two techniques were applied in the dereplication and identification of bioactive compounds from a Streptomyces sp. (SM8) isolated from the sponge Haliclona simulans from Irish waters. Streptomyces strain SM8 extracts showed antibacter...

Endophytic fungi produce a plethora of secondary metabolites, which may open new avenues to study their applicability in pharmaceuticals. Therefore, the present focuses on fungal endophytic community Artemisia asiatica. During our work, endophytes were isolated from medicinal plant, A. The culturable identified using molecular techniques and biodiversity, richness tissue specificity examined. A...

BACKGROUND & OBJECTIVE Dermatophytes responsible for causing dermatophytoses in humans have acquired resistance to certain antimycotic drugs. We isolated naturally occurring actinomycetes with an ability to produce metabolites having antimycotic property. The timecourse of antifungal metabolite production in terms of arbitrary units (AU) under optimum conditions was studied. METHODS Water and...