The data on the protective properties of Prunella grandiflora L. extract were obtained when used together with anticancer drug etoposide experimental strain Drosophila melanogaster . combined use and 10% P. decreased mortality in D. individuals to 15% doubled average individual fertility compared this cytostatic without extract. Using SMART method, presence antigenotoxic effect was identified, ...

The chalcones (E)-3-(4-chlorophenyl)-1-phenyl-2-propen-1-one (4-CL) and (E)-3-(3,4-dimethoxyphenyl)-1-phenyl-2 -propen-1-one (DMF) are versatile easily synthesized into low-cost compounds that have a wide spectrum of biological activities. In this study, the cytotoxic, genotoxic modulatory activities 4-CL DMF were evaluated using Ames test mouse micronucleus assay. results revealed both did not...

Background: Organophosphorus pesticides has been widely used in agriculture fields to control various crop insects and their extensive use pose human life at threat because of their adverse effects on human health. In this study, we checked the effects of GST polymorphism on ameliorative effect of curcumin and carvacrol against DNA damages. Methods: Comet assay was used to assess the DNA dam...

Figure 1. Antigenotoxic activity of Borago officinalis plant material: (a) blue flowered (BF) and (b) white flowered (WF) plant material expressed as mutation frequency corrected to control. Strength of inhibition on the capability of H2O2 (0.12 M) to induce mutated cells is also shown (Inhibition Percentage in brackets). White columns correspond with tested concentrations of simple treatments,...

BACKGROUND Napoleona vogelii is used in traditional medicine for cancer management. AIM The study was conducted to evaluate the antigenotoxic and antioxidant activities of methanol stem bark extract of N. vogelii in male Sprague Dawley rats. MATERIALS AND METHOD Thirty male Sprague Dawley rats were randomly divided into group 1 (control) administered 10 mL/kg distilled water, groups 2 and 3...

Orange juice (OJ) is among the most consumed fruit juices worldwide, and its chemopreventive action is fairly addressed in the literature. This review critically presents the available evidence linking OJ with cancer chemoprevention and on discussing the putative mechanisms and negative health effects. The chemopreventive action of OJ is related to its effect on metabolic enzymes and its antiin...

Application of exogenic bioactive natural plant compounds with protective, anti-mutagenic and anti-genotoxic effects against various chemical and physical agents is one of the modern approaches for reduction of the mutagenic burden of cells. Objective: The present study aims to provide data on the cytoxic and genotoxic effects of Papaver rhoeas L. water leaf extract and its anti-cytotoxic and a...