Abstract Development of resistance by malaria parasites to conventional antimalarial drugs has rejuvenated the exploration herbal medicine as alternatives. Also, increasing rate use remedies in combination with (both synthetic and semi-synthetic) inspired researchers validate their herb-drug interaction effects. This review evaluated outcomes between drugs. With aid electronic databases, Pubmed...

INTRODUCTION We evaluated the in vitro antimalarial activity of tigecycline as an alternative drug for the treatment of severe malaria. METHODS A chloroquine-sensitive Plasmodium falciparum reference strain, a chloroquine-resistant reference strain, and three clinical isolates were tested for in vitro susceptibility to tigecycline. A histidine-rich protein in vitro assay was used to evaluate ...

Malaria is a hematoprotozoan parasitic infection transmitted by certain species of anopheline mosquitoes. Four species of Plasmodium commonly infect humans, but Plasmodium falciparum, accounts for the majority of instances of morbidity and mortality. There has been a resurgence of interest in malaria in recent years because the efforts at control have foundered after the failure of the global e...

Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes preclinical murine and experimental human infection studies to evaluate efficacy.

Malaria is still a serious public health problem in some parts of the world. The problems of recurrence and drug resistance are increasingly more serious. Thus, it is necessary to develop a novel antimalarial agent. The objectives of this study were to construct a novel compound antimalarial transdermal nanosystem-ethosomal cataplasm, to investigate its characteristics and efficiency, and to sy...

Considering malaria is a highly devastating disease of mankind, total eradication of malaria seems to be an uphill task, the only relief from this disease is achieved by usage of antimalarial drugs. Since malaria is associated with humans from time immemorial, usage of traditional substances to most presently effective antimalarial have been recorded to cure this disease. With the advent of mod...

Menadione is the 2-methyl-1,4-naphthoquinone core used to design potent antimalarial redox-cyclers to affect the redox equilibrium of Plasmodium-infected red blood cells. Exploring the reactivity of fluoromethyl-1,4-naphthoquinones, in particular trifluoromenadione, under quasi-physiological conditions in NADPH-dependent glutathione reductase reactions, is discussed in terms of chemical synthes...

The use of antimalarial drugs in India has evolved since the introduction of quinine in the 17 th century. Since the formal establishment of a malaria control programme in 1953, shortly after independence, treatments provided by the public sector ranged from chloroquine, the mainstay drug for many decades, to the newer, recently introduced artemisinin based combination therapy. The complexity o...

Chalcones (1, 3, diaryl-2-propen-1-ones), are one of the plant secondary metabolite belonging to flavonoid family and has been widely explored in past decennium for its various pharmacological activities including antimalarial activity. Plasmodium aspartate proteases and cysteine proteases are the promising targets in malarial chemotherapy to overcome the drug resistance. Chalcones supposed to ...