C. Ichino, N. Soonthornchareonnon, W. Chuakul, H. Kiyohara, A. Ishiyama, H. Sekiguchi, M. Namatame, K. Otoguro, S. Omura and H. Yamada* The Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand Oriental Medicine Research Center, The Kitasato Institute, Tokyo, Japan Research Center for Tropical Diseases, Institute...

the formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. in this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. fifteen extracts with different polarity from three iranian artemisia species, a. ciniformis, a. biennis an...

This study was conducted to determine the in vitro anti-malarial activity of three medicinal plants, Picrorhiza kurroa, Caesalpinia bonducella and Artemisia absinthium of Pakistan. Different extracts of various parts of these plants were prepared by maceration and percolation, and were evaluated for their antimalarial activity. Aqueous, cold alcoholic and hot alcoholic extracts of Picrorhiza ku...

Sir, A recent issue of the Malaria Journal has been dedicated to the research and development of natural products for treatment of malaria. All the articles in the issue are interesting. The article on Reverse Pharmacology (RP) by Willcox et al [1] is of particular interest, which suggested that this transdiscipline of RP has global appeal. The RP path, as Willcox et al have rightly mentioned i...

Malaria is a major public health problem in many tropical and subtropical countries and the burden of this disease is getting worse, mainly due to the increasing resistance of Plasmodium falciparum against the widely available antimalarial drugs. There is an urgent need for discovery of new antimalarial agents. Herbal medicines for the treatment of various diseases including malaria are an impo...

BACKGROUND Resistance of malaria parasites to existing drugs complicates treatment, but an antimalarial vaccine that could protect against this disease is not yet available. It is therefore necessary to find new effective and affordable medicines. Medicinal plants could be a potential source of antimalarial agents. Some medicinal plants from Burkina Faso were evaluated for their antiplasmodial ...

Malaria is an infectious disease that arises from the presence of parasitic protozoa of the genus plasmodium within the RBC. The disease is confined to tropical and sub-tropical regions of the world and is transmitted by the female anopheles mosquito. The bites of a mosquito inject the parasite into the bloodstream and this migrates to the liver and other organs where they multiply. With varyin...

The investigation of Thai medicinal plants for the potential therapeutic agents is surveyed with a particular emphasis on the search for antimalarial agents. The study on Diospyros mollis, Croton sublyratus, and Phyllanthus amarus is described. Thailand is uniquely located to represent the fauna and flora which characterizes the biogeographic province of Indo-Burma. A number of the eastern Hima...

Various combinations of Nauclea latifolia root, Artocarpus altilis stem bark, Murraya koenigii leaf and Enantia chlorantha stem bark used in African ethnomedicine as decoctions for malaria and fevers, and combinations with standard drugs, were investigated for antiplasmodial activities using Plasmodium berghei berghei-infected mice. The respective prophylactic and curative ED50 values of 189.4 ...

Methanolic extracts from 15 medicinal plants representing 11 families, used traditionally for malaria treatment in Kenya were screened for their in vivo antimalarial activity in mice against a chloroquine (CQ)-tolerant Plasmodium berghei NK65, either alone or in combination with CQ. The plant parts used ranged from leaves (L), stem bark (SB), root bark (RB), seeds (S) and whole plant (W). When ...