Antimicrobial agents active against multi-resistant Gram-positive bacteria are considered to be of major commercial potential. Commercially viable agents that have been included in recent successful trials include the streptogramins, novel glycopeptides, oxazolidinones and potent quinolones. Cationic peptides have generated much interest, but their utility as successful drug candidates remains ...

background: the development of resistance to antimicrobial agents is a major problem in chemotherapy. finding agents which potentiate antimicrobial activity could be favorable. there are some reports that methylxanthines changed the inhibitory effect of antibacterial agents. thus, possible synergistic effect of methylxanthines, aminophylline and caffeine on some antibiotics, carbenicillin, ceft...