The halogenated salicylanilides are a large group of compounds developed mainly for their antiparasitic activity in animals. Several halogenated salicylanilides with potent antiparasitic activity have been synthesised of which only closantel, niclosamide, oxyclozanide, rafoxanide and resorantel are commercially available. Closantel and rafoxanide, which represent the most important drugs in the...

There is no consensus on the benefits of treatment with any specific anthelminthic compound on muscle-stage trichinosis. A double-blind, placebo-controlled comparison was done of 3 antiparasitic drugs during an outbreak of trichinosis in Chiangrai Province, northern Thailand. Forty-six adults were randomized to receive 10 days of oral treatment with mebendazole (200 mg twice a day), thiabendazo...

Silver nanoparticles (AgNPs) are ultra-small silver particles with a size from 1 to 100 nanometers. Unlike bulk silver, they have unique physical and chemical properties. Numerous studies shown that AgNPs beneficial biological effects on various diseases, including antibacterial, anti-inflammatory, antioxidant, antiparasitic, antiviruses. One of the most well-known applications is in field anti...

The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model ca...

BACKGROUNDS: Occurrence of resistance against antiparasitic drugs has made it essential for researchers to find new sources for antiparasitic drugs. OBJECTIVES: This study was performed to determine the efficiency of alcoholic extract of worm wood (Artemisia absinthium) on Syphasia parasite. METHODS: Artemisia absinthium extract was examined on 3 groups of mice at 2.5%, 5% and 10% concentration...

Given the amount of scientific knowledge produced and published daily about new corovavirus, this study sought to review evidence on some drugs used treat Acute Respiratory Infection Syndrome caused by COVID-19 virus. Thus, antimalarials antiparasitics were evaluated regarding chemical pharmacological aspects, including mechanism action, toxicity, adverse effects recommendation for use in treat...

The in vitro activity on Leishmania infantum promastigotes and Trypanosoma cruzi epimastigotes of 25 semisynthetic terpenoid derivatives has been evaluated. These compounds were obtained through chemical modifications of the major components of Euphorbia resinifera (alpha-euphol and alpha-euphorbol) and Euphorbia officinarum (obtusifoliol and 31-norlanosterol). Leishmaniasis and Chagas' disease...