Background: There is a growing interest in development of an effective adjuvant system for improving DNA vaccines. Recent findings have confirmed an important role for autophagy in both innate and adaptive immunity. The current study was undertaken to determine the efficacy of autophagy induction with Beclin-1, as a novel adjuvant system, in mice immunized with human papilloma virus (HPV) DNA v...

The antitumor activity of ethanol extract of Prosopis glandulosa Torr. (EPG) was evaluated against Ehrlich ascites carcinoma (EAC) tumor model in Swiss albino mice on dose dependent manner. The activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. Oral administration of EPG at the dose of 100, 200 and 400 mg/Kg, significantl...

We evaluated the antitumor effect of combined therapy with tegafur/uracil (UFT) plus leucovorin (LV) (UFT/LV) and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma, and the antitumor effect was enhanced when PSK given concomitantly. UFT/LV showed antitumor effect to Lewis lung carcinoma and PSK alone also sho...

the antitumor activity of ethanol extract of prosopis glandulosa torr. (epg) was evaluated against ehrlich ascites carcinoma (eac) tumor model in swiss albino mice on dose dependent manner. the activity was assessed using survival time, average increase in body weight, hematological parameters and solid tumor volume. oral administration of epg at the dose of 100, 200 and 400 mg/kg, significantl...

Self-assembled dasatinib nanoparticles exhibited aggregation-induced emission with high antitumor activity.

CLINICAL QUESTION What is the best approach to the treatment of drug-resistant tuberculosis (TB)? RESULTS Evidence-based treatment of drug-susceptible TB is the best means of preventing the development of drug-resistant disease. Suspecting the possibility of drug-resistant TB, and prompt detection of all forms of drug-resistant TB, not only multidrug-resistant and extensively drug-resistant T...

OVERCOMING TUMOR DRUG RESISTANCE BY ACTIVATING AMP-ACTIVATED PROTEIN KINASE AND DESTABILIZING ONCOPROTEINS