Vitiligo has been associated with the host's genetic profile, metabolic abnormality and immunostatus. The purpose of this study was to investigate the association of vitiligo with autoimmune diseases for 31 out of 39 subjects with vitiligo and their first-degree relatives living in a small Caucasian inbred rural community. They were compared with healthy individuals. A 2.28% prevalence of vitil...

OBJECTIVES To investigate the occupational and genetic risk factors inducing lumbar disc degeneration in a Chinese population, and to explore their synergistic interactions. METHODS A case-control study involving 178 low back pain patients with lumbar disc degeneration and 284 controls was carried out. Five types of work-related factors were investigated using questionnaires. Polymerase chain...

Alternative polyadenylation (APA) is an important regulatory mechanism of gene functions in many biological processes. However, the extent of 3' UTR variation and the function of APA during the innate antiviral immune response are unclear. Here, we show genome-wide poly(A) sites switch and average 3' UTR length shortens gradually in response to vesicular stomatitis virus (VSV) infection in macr...

the activity of angiotension converting enzyme (ace; omim: 106180) in different brain regions of patients with schizophrenia changed, suggesting a possible involvement of ace in psychiatric disorders. genetic polymorphism of insertion/deletion (i/d; dbsnp rs4646994) in the gene encoding ace has been well defined.the present case-control study was performed on 363 (268 males, 95 females) in-pati...

Previous work from our laboratory [1] has established the efficient syntheses of lysine (APA-Lys)* and ornithine (APA-Orn) analogues of the folate antagonist drug methotrexate (MTX). Both analogues are potent inhibitors of dihydrofolate reductase (DHFR) , the intracellular target for MTX and other antifolate drugs. Reaction of APA-Lys and APA-Orn with dansyl chloride furnishes the corresponding...

diabetes mellitus is a multifactorial disease. it has recently been shown that an insertion (i)/deletion (d) polymorphism exists in the angiotensin-converting enzyme (ace) gene that can affect the serum ace level. there are three genotypes: dd, di, and ii, with the ace level being highest in dd, intermediate in di, and lowest in ii. in the present investigation, 170 patients with type 2 diabete...

Sport, Exercise, and Performance Psychology (SEPP), the official journal of Division 47 (Society for Sport, Exercise & Performance Psychology) of the American Psychological Association (APA), is now in its sixth year of publication. Jeff Martin, the first Editor, has done a fantastic job in establishing SEPP as one of the leading journals in the field of sport, exercise, and performance psychol...

Background. The persistent presence of antiphospholipid antibodies (APA) may lead to the development of primary or secondary antiphospholipid syndrome. Although the genetic basis of APA has been suggested, the identity of the underlying genes is largely unknown. In this study, we have performed a genome-wide association study (GWAS) in an effort to identify susceptibility loci/genes for three m...