We report herein a radical-mediated amination of cyclopropenes. The transformation proceeds through cleavage the three-membered ring after addition an azide radical on strained double bond and leads to tetrasubstituted alkenyl nitrile derivatives upon loss N2. With 1,2-diaryl substituted cyclopropenes, this methodology could be extended one-pot synthesis highly functionalized polycyclic aromati...

a mild, green and highly efficient route for regio-selective amination of oxiranes was developed via incorporation of mn(ii), fe(ii), co(ii), ni(ii), cu(ii) and zn(ii) cations onto the surface of hydroxyapatite-encapsulated γ-fe2o3 nanoparticles (γ-fe2o3@hap). among six magnetically recoverable catalytic systems denoted as [γ-fe2o3@hap-mii], the catalyst in which m designated as fe(ii) showed t...

Transaminases are valuable enzymes for industrial biocatalysis and enable the preparation of optically pure amines. For these transformations they require either an amine donor (amination of ketones) or an amine acceptor (deamination of racemic amines). Herein transaminases are shown to react with aromatic β-fluoroamines, thus leading to simultaneous enantioselective dehalogenation and deaminat...

Amination of 4-nitrophenol, umbelliferone and 4-methylumbelliferone gave the corresponding oxyamines 1-3. These oxyamines react with aldehydes and ketones to form oximes. In the case of aliphatic aldehydes and electron-poor aromatic aldehydes, the oximes undergo base-catalyzed fragmentation in aqueous buffer in the presence of bovine serum albumin to give the parent phenols, which is the acycli...

Abstract N-Aryl-1,2,3,4-tetrahydroisoquinolines are obtained via a convenient and short protocol with broad range of substituents on both aromatic rings high functional group tolerance. Starting from readily available ortho-brominated aldehydes primary amines, condensation these building blocks under reductive conditions gives N-aryl 2-bromobenzylamines. The C-3/C-4-unit the tetrahydroisoquinol...

A mild, efficient and regioselective method for para-amination of activated arenes has been developed through a combination of iron and copper catalysis. A diverse range of products were obtained from an operationally simple one-pot, two-step procedure involving bromination of the aryl substrate with the powerful Lewis acid iron(III) triflimide, followed by a copper(I)-catalysed N-arylation rea...