Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity of the CNS results from the growth-inhibitory environment that impedes the regrowth of axons. Central neural tissue engi...

The liver is an amazing organ because it can regenerate. The differentiated parenchymal cells, which do not normally divide, can undergo multiple rounds of cellular division. This brings into question the exact role of the liver stem-cell, which has not been fully characterized. The knowledge gained from the dissection of the basic molecular and cellular events that occur during hepatic regener...

OBJECTIVE Artificial nerve guides are being developed to substitute for autograft repair after peripheral nerve injuries. However, the use of conduits is limited by the length of the gap that needs to be bridged, with the success of regeneration highly compromised in long gaps. Addition of aligned proregenerative cells and extracellular matrix (ECM) components inside the conduit can be a good s...

IntroductIon: Peripheral nerve injury is a common and debilitating consequence of traumatic injury. Surgical repair of peripheral nerve by repositioning results in a degree of nerve regeneration and functional recovery. However, the clinical outcome, particularly in long length nerve defects, is disappointing and research continues to develop approaches to optimize functional recovery. An appro...

There are three major approaches for regenerative medicine. The most innovative approach among them is: induction of target cells from various stem cells such as induced pluripotent stem cells (iPS cells) or embryonic stem cells (ES cells) and implantation of them to regenerate the organ. The second approach is: in vitro tissue regeneration that involves preparation of artificial tissue by comb...

At a recent Keystone Symposium on 'Developmental Biology and Tissue Engineering', new findings in areas ranging from stem cell differentiation, embryonic pattern formation and organ regeneration to engineered cell microenvironments, synthetic biomaterials and artificial tissue fabrication were described. Although these new advances were exciting, this symposium clarified that biologists and eng...

The model of extended repeated partial hepatectomy without vascular shunt in dogs is presented. It consisted of 65% initial hepatectomy and after liver regeneration (6-10 weeks) repeated hepatectomy. Finally, only the papillary process of the caudate lobe (PPC), which constitutes 5% of the initial hepatic mass, was left intact. The most important finding was an ability of PPC to reconstitute th...

IntroductIon: Peripheral nerve injury is a common and debilitating consequence of traumatic injury. Surgical repair of peripheral nerve by repositioning results in a degree of nerve regeneration and functional recovery. However, the clinical outcome, particularly in long length nerve defects, is disappointing and research continues to develop approaches to optimize functional recovery. An appro...

A novel artificial bone substitute composed of bioactive MegaGen synthetic bone (MGSB) and hyaluronate (HA) hydrogels was successfully developed for bone tissue engineering applications. HA is known to play important roles in bone regeneration due to its angiogenic and osteoconductive characteristics. Accordingly, HA hydrogel was designed to supply HA continuously for effective bone regeneratio...