Elevated levels of beta-amyloid (Abeta) in the brains being a hallmark of Alzheimer's disease (AD) have been believed to play a critical role in the cognitive dysfunction that occurs in AD. Recent evidence suggests that Abeta induces neuronal apoptosis in the brain and in primary neuronal cultures. In this study, we investigated the effects of beta-asarone, the major ingredient of Acorus Tatari...

ABSTRACT The Asian traditional medicinal plant Acorus calamus and its component α-asarone exhibited various biological activities, such as antiinflammation antioxidant effects. In the present study, we investigated in vitro effects of A. extract on oxidative stress- endoplasmic reticulum (ER) stress–induced cell death hippocampal HT22 cells. both significantly suppressed induced by stress induc...

BACKGROUND The rhizomes of a herb Acorus calamus Linn. (Acoraceae) have been widely used as a traditional medicine to cure intestinal-helminthic infections in India and South Africa. AIM This study was undertaken to investigate the in vivo anthelmintic activity of a standardized methanolic extract obtained from the rhizomes A. calamus in a rodent model. MATERIALS AND METHODS A methanolic ex...

JHMR: http://escipub.com/journal-of-herbal-medicine-research/ 0007 Figure 1 Beta-asarone down-regulates stroke injury through decreasing autophagy. Xu, JHMR, 2016; Vol. 1(1): 0007-0009 JHMR: http://escipub.com/journal-of-herbal-medicine-research/ 0008 INTRODUCTION Stroke is one of the primary cause of longterm disability, no matter in developing or developed countries. In United States of Ameri...

BACKGROUND Calamus (Acorus calamus Linn., Araceae) rhizome synonymously called sweet flag or Vacha is an aromatic herb indigenous to Central Asia and Eastern Europe. It has been used by the Ayurvedic practitioners since time immemorial for diseases ranging from weakness of memory to being used as an anthelminthic. Reports of its use have been found in books like Charak Samhita, Sushruta Samhita...

The air stable asarone-derived Ru carbene 16, a robust olefin metathesis catalyst, can be easily separated after reaction by deposition on silica gel and reused up to nine times. This procedure provides products of excellent purity with low Ru content.

Abstract Background Metabolic dysregulation is one of the hallmarks tumor cell proliferation. Evidence indicates potential role 5′adenosine monophosphate-activated protein kinase (AMPK) and B/Akt signaling pathway in regulating proliferation, survival, apoptosis. The present study explores effect metformin HCl combination α- β-asarone on proliferation HepG2 cells presence high glucose levels si...

The widespread use of naturally occurring alkenylbenzenes as flavoring and fragrance agents has led to a long-standing interest in their toxicity and carcinogenicity. Among them several allyl- and propenylbenzenes have been found to be mutagenic and carcinogenic. It has been shown that the carcinogenicity of several allylbenzenes can be related to the formation of electrophilic sulfuric acid es...

The rhizomes of Acorus gramineus have frequently been used in traditional medicine mainly for sedation as well as enhancing brain function. In this study, the anti-allergic activity of A. gramineus was investigated. The 70% ethanol extract of the rhizomes of A. gramineus was found to inhibit the allergic response against 5-lipoxygenase (5-LOX)-catalyzed leukotriene (LT) production from rat baso...