Idiopathic pulmonary fibrosis (IPF) is a chronic disease with a poor prognosis and is characterized by the accumulation of fibrotic tissue in lungs resulting from a dysfunction in the healing process. In humans, the pathological process is patchy and temporally heterogeneous and the exact mechanisms remain poorly understood. Different animal models were thus developed. Among these, intratrachea...

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Hepatocyte growth factor (HGF) is a humoral mediator of epithelial-mesenchymal interactions, acting on a variety of epithelial cells as mitogen, motogen, and morphogen. Exogenous HGF acts as a hepatotrophic factor and a renotrophic factor during experimental injury. To investigate whether HGF has a pulmotrophic function, human recombinant HGF was administered to C57BL/6 mice with severe lung in...

Idiopathic pulmonary fibrosis (IPF) is characterised by myofibroblast proliferation leading to architectural destruction. Neither the origin nor the continued proliferation of myofibroblasts is well understood. Explanted human IPF lungs were stained by immunohistochemistry for calretinin, a marker of pleural mesothelial cells (PMCs). Chronic obstructive pulmonary disease (COPD) and cystic fibro...

drawing largely on aidoo’s (1970) play, anowa, as well as lived experiences, i argue on the philosophical flaws of ashcroft’s (2009) claim that there is no inherent link between language and culture. this essay subsequently explores the implication of my argument on some transformational domains of english in particular though it has obvious applicability to the role of colonial languages in ge...

Sulfonylureas are anti-diabetic medications that act by inhibiting pancreatic KATP channels composed of SUR1 and Kir6.2. The mechanism by which these drugs interact with and inhibit the channel has been extensively investigated, yet it remains unclear where the drug binding pocket resides. Here, we present a cryo-EM structure of the channel bound to a high-affinity sulfonylurea drug glibenclami...

It is rarely cost-effective to survey invertebrates for use in systematic conservation planning activities. The efficiency of sampling methods needs to be improved, and this is especially important at landscape and regional scales. We investigated two methods that could be used to improve regional scale sampling efficiency using a case study of ants, beetles, flies, bugs, spiders and wasps from...

British Journal of General Practice, October 2009 721 REFERENCES 1. Taylor K. Asylum seekers, refugees, and the politics of access to health care: a UK perspective. Br J Gen Pract 2009; 59(567): 765–772. 2. Ashcroft RE. Standing up for the medical rights of asylum seekers. J Med Ethics 2005; 31(3): 125–126. 3. Cole P. Human rights and the national interest: migrants, healthcare and social justi...