− There’re mainly two different situations for testing PLD (Programmable Logic Device) devices. One is testing of blank chips that haven’t been programmed; the other is testing of ASIC (Application Specific Integrated Circuit) devices that have been programmed. This paper presents a test method for programmed ASIC devices, including auto test and ATPG (Auto Test Pattern Generation) method for b...

The physical scaling following Moore’s law is saturated while the requirement on computing keeps growing. The gain from improving silicon technology is only the shrinking of the silicon area, and the speedpower scaling has almost stopped in the last two years. It calls for new parallel computing architectures and new parallel programming methods. Traditional ASIC (Application Specific Integrate...

The epithelial sodium (Na ) channel (ENaC) plays a critical role in blood pressure regulation by controlling renal salt and water reabsorption. Channel overactivity can lead to severe hypertension and underactivity to salt wasting and hypotension.1 In addition to their role in salt/water homeostasis, recent studies suggest that ENaC proteins, and their relatives, the acid-sensing ion channel (A...

Rooj AK, Liu Z, McNicholas CM, Fuller CM. Physical and functional interactions between a glioma cation channel and integrin1 require -actinin. Am J Physiol Cell Physiol 309: C308–C319, 2015. First published June 24, 2015; doi:10.1152/ajpcell.00036.2015.—Major plasma membrane components of the tumor cell, ion channels, and integrins play crucial roles in metastasis. Glioma cells express an amilo...

Hardware implementation quality is an important factor in selecting the NIST SHA-3 competition finalists. However, a comprehensive methodology to benchmark five final round SHA-3 candidates in ASIC is challenging. Many factors need to be considered, including application scenarios, target technologies and optimization goals. This work describes detailed steps in the silicon implementation of a ...

Previously we demonstrated that chronic hypoxia (CH) induces an inflammatory condition characterized by immune cell invasion and increased expression of inflammatory cytokines in rat carotid body. It is well established that chronic inflammatory pain induces the expression of acid-sensitive ion channels (ASIC) in primary sensory neurons, where they contribute to hyperalgesia and allodynia. The ...

Abstract To address knowledge gaps in management of Gram-negative bloodstream infections (GN-BSI), the Antibiotic Stewardship Implementation Collaborative (ASIC) programs from 24 academic and community hospitals across United States was established. Herein, we describe microbiology antibiotic susceptibility patterns GN-BSI isolates contributed by ASIC sites.

In the next years, new hash function candidates will replace the old MD5 and SHA-1 standards and the current SHA-2 family. The hash algorithms RadioGatún and irRUPT are potential successors based on a stream structure, which allows the achievement of high throughputs (particularly with long input messages) with minimal area occupation. In this paper, several hardware architectures of the two ab...

Hardware implementation quality is an important factor in selecting the NIST SHA-3 competition finalists. However, a comprehensive methodology to benchmark five final round SHA-3 candidates in ASIC is challenging. Many factors need to be considered, including application scenarios, target technologies and optimization goals. This work describes detailed steps in the silicon implementation of a ...

Acid-sensing ion channels (ASIC) are voltage-insensitive, cationic channels that have recently been identified in vascular smooth muscle (VSM). It is possible that ASIC contribute to vascular reactivity via Na(+) and Ca(2+) conductance; however, their function in VSM is largely unknown. In pulmonary VSM, store-operated Ca(2+) entry (SOCE) plays a significant role in vasoregulatory mechanisms su...