A new beta-adrenergic receptor blocking agent, ICI.50,172, has been compared with propranolol with respect to the effects on airway resistance (AWR), forced expiratory volume (FEVi) and pulse rate. AWR was measured by body plethysmography. The drugs were given intravenously to ten asthmatic patients on different occasions. ICI.50,172 caused no subjective alteration of their respiratory conditio...

The effects of oral doses of theophylline and a iS-adrenergic agonist, fenoterol, were examined in 18 asthmatic young adults. Significant bronchodilation was seen with high-dose theophylline (FEy1 increased 14 percent) and with full 10-mg doses of fenoterol (FEV, increased 10 percent). Low-dose theophylline alone (130 mg) increased FEV1 by 5 percent, but when combined with 5 mg of fenoterol, a ...

A new drug, AH 7725, with properties similar to those of disodium cromoglycate (Intal) has the additional feature of being effective when taken by mouth. Six patients with allergic asthma were studied by bronchial challenge tests with antigen. In every one the drug was found to inhibit (either partially or completely) the immediate-type asthmatic response. Late responses were not influenced. Th...

BACKGROUND The purpose of this study was to examine the relationship between the type of inhaled medication, length of use, dosing, the inhaler use technique and the severity and duration of disease on the dental caries of asthmatic patients. OBJECTIVES In the present study, the frequency of dental caries in the asthmatic patients and control group was examined. In addition the possible assoc...

Sixteen chronic asthmatic patients inadequately controlled by drugs had, after one year of hypnotherapy, a fall in admissions from 44 in the year before starting therapy to 13 in the year after. Duration of stay was reduced for 13 patients by 249 days; prednisolone was withdrawn in 6, reduced in 8 and increased in none. Side effects of drugs were reduced. Although 62% reported improvement on a ...

No studies have examined the influence of factors such as exercise and dehydration on the pharmacokinetic profile of asthmatic drugs (beta2agonists). Exercise may modify the metabolism and excretion of drugs, and sweat loss during exercise can result in dehydration, both affecting the urine concentration of the drug. Furthermore, most current pharmacokinetic studies of beta2-agonists have been ...

Although inflammation is an important component of atherosclerosis, it is unknown whether inhaled corticosteroids (ICS) as anti-inflammatory drugs prevent atherosclerosis. In the present study, carotid atherosclerosis was evaluated by ultrasonography in 150 asthmatic patients who had been regularly treated with ICS, and in 150 matched nonasthmatic controls, with an assessment of atherosclerotic...

The role of cysteinyl leukotrienes (cys-LTs) and thromboxane A(2) (TXA(2)) in guinea pig models of aspects of bronchial asthma was investigated. In a novel antigen (BSA)-induced asthmatic model using passively sensitized guinea pigs, pretreatment with varying doses of indomethacin controlled the ratio of followed lipid mediators, LTC(4)/D(4)/E(4) and TXB(2), in lungs of challenged guinea pigs. ...

induced by toluene diisocyanate. Am Rev Respir Dis, 1987, 136, 36-42. 8. Boschcuo P, Fabbri LM, Zocca E. Milani OF, Pivirotto P, Dal Vecchio A, Plebani M, Mapp CB. Prednisone inhibits late asthmatic reactions and airway infli!Jllmation induced by toluene diisocyanate in seruitiz.ed subjects. J Allergy Clin lmmunol, 1987, 80, 261267. 9. Fabbri LM, Di Giaromo R. Dal Vecchio L, Zocca E, De Marzo N...