To examine the role of ataxia-telangiectasia mutated (Atm) in telomere function, we generated Atm and telomerase null mice (Atm(-/-) mTR(-/-) iG6 mice). These mice exhibited increased germ cell death and chromosome fusions compared with either Atm(-/-) or mTR(-/-) iG6 mice. Furthermore, the Atm(-/-) mTR(--) iG6 mice had a delayed onset and reduced incidence of thymic lymphoma compared with Atm(...

During the recent years more and more attention has been focused on the usage of Asynchronous Transfer Mode (ATM) in the wireless environment. Third generation mobile network standards like UMTS and IMT-2000 have chosen ATM as a transport technology candidate for terrestial circuits in cellular networks. Why ATM? A prototype system called CATMES, Cellular ATM Evaluation System, was created to i...

ataxia-telangiectasia (at) is an autosomal recessive disorder involving cerebellar degeneration, immunodeficiency, radiation sensitivity and cancer predisposition. the atm gene on human chromosome 11q22.3 has recently been identified as the gene responsible for ataxia-telangiectasia (at). the gene mutated in at, which has been designated as the atm gene, encodes a large protein kinase with a pi...

Ataxia telangiectasia mutated (ATM) plays a critical role in the cellular response to DNA damage. In response to DNA double-strand breaks (DSBs), ATM is autophosphorylated at serine 1981. Although this autophosphorylation is widely considered a sign of ATM activation, it is still not clear if autophosphorylation is required for ATM functions including localization to DSBs and activation of ATM ...

This transparent cell transport service allows migration of ATM services to a PSN without having to provision the ATM subscriber or customer edge (CE) devices. The ATM CEs will view the ATM transparent cell transport service as if they were directly connected via a Time Division Multiplexer (TDM) leased line. This service is most likely to be used as an internal function in an ATM service provi...

ATM has been successfully used in Wide Area Networks (WAN) and Local Area Networks (LAN). A possible next step in this evolution is to use ATM for memory interconnect. This paper discusses how ATM can fulfill the functional and performance requirements in a memory interconnect, and the implications this will have for external ATM communication. We conclude that ATM can be used as a memory inter...

The future development of air traffic management (ATM), set by the ATM 2000+ Strategy, involves a structural revision of ATM processes, a new ATM concept and a system approach for the ATM network. This requires ATM services to go through significant structural, operational and cultural changes that will contribute towards the ATM 2000+ Strategy. Moreover, from a technology viewpoint, future ATM...

The advances in processing and networking technology will make it feasible to develop parallel and distributed computing applications that run on a variety of networked computing resources. Using high-speed networks, these resources can work together to speed up both computations and I/Os, and can incorporate a large amount of memory. ATM network has the potential to achieve parallel and distri...