BACKGROUND/AIMS The aim of the present study is to investigate whether the single nucleotide polymorphism (SNP) in lipid metabolism related genes would affect the effectiveness of atorvastatin in both Han and Uighur populations. METHODS 200 ischemic stroke patients were treated with atorvastatin. The differences of blood lipid level and their ratios were measured. Six lipid related genes, HMG...

The degradation of atorvastatin calcium in methanol and hydrogen peroxide results in the crystallization of the title compound, C(26)H(24)FNO(6), which shows several differences compared with the starting compound. In the crystal structure of the title compound, intra- and inter-molecular hydrogen bonding is found.

A substantial number of new chemical entities and marketed drugs show poor solubility characteristics and amorphisation is one of the favorable approaches to enhance solubility characteristics of such poorly soluble drugs. Formulation efforts in the present study were devoted to investigate amorphisation of a model poorly soluble drug, atorvastatin calcium by molecular complexation with anion e...

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are effective agents in lowering cholesterol and triglycerides and are being used by human immunodeficiency virus-positive patients to treat the lipid elevation that may be associated with antiretroviral therapy. Many HMG-CoA reductase inhibitors and protease inhibitors are metabolized by the same cytochrome P450 enzyme 3A4 (C...

A new method is proposed for the analysis of a ternary mixture composed of clopidogrel, atorvastatin, and aspirin without prior separation steps. The method combines the advantages of the mean centering of ratio spectra and derivative spectrophotometric methods. It is based on using the difference between adjacent data points in the absorbance spectra. The principal advantage of this method is ...

Quantitative nuclear magnetic resonance (qNMR) is a powerful tool in measuring drug content because of its high speed, sensitivity, and precision. Most of the reports were based on proton qNMR ((1)H qNMR) and only a few fluorine qNMR ((19)F qNMR) were reported. No research has been conducted to directly compare the advantage and disadvantage between these two methods. In the present study, both...

Two accurate, precise, sensitve and economical procedures for simultaneous estimation of atorvastatin calcium and telmisartan in tablet dosage forms have been developed. First method employs formation and solving of simultaneous equations using 219 nm and 257nm as two analytical wavelengths for both drugs in 0.1 N NaOH. The second method is Qanalysis based on measurement of absorptivity at 240n...

BACKGROUND There are no randomized controlled trials of statin therapy in patients with severe bronchiectasis who are chronically infected with Pseudomonas aeruginosa. METHODS Thirty-two patients chronically infected with P aeruginosa were recruited in this double-blind cross-over randomized controlled trial. Sixteen patients were recruited in each arm, were given atorvastatin 80 mg or placeb...

The present study describes development and validation of UV-spectroscopic method for estimation of Atorvastatin calcium in tablet dosage form. During development of analytical method water, phosphate buffer, methanol were tried but drug was found to be soluble in methanol. Standard stalk solution was prepared in methanol. λmax was found to be 246nm. Calibration curves were prepared. The propos...