Our laboratory is engaged in an ongoing analysis of a 103-compound data set containing reliable intravenous pharmacokinetic parameters in the rat, dog, monkey, and human, and we have previously reported our findings regarding extrapolation of clearance. In this article, we report on our findings regarding volume of distribution and mean residence time. Various allometric and nonallometric metho...

Sequences of residence times (RTs) associated with the escape from metastable states are observed in many fields. Here we study analytically and numerically the correlations among RTs for a bistable stochastic system driven by dichotomous noise. Our theory predicts an oscillatory behavior of the correlations with respect to the lag between RTs. Correlations vanish at all lags if the switching r...

The authors examined the association between perceived safety of neighborhood and likelihood of exercise among adult residents of eight European cities. Data were collected by a survey of neighborhood, housing, and health conducted by the World Health Organization in 2002 and 2003. Baseline category logistic regression models were fit to estimate the association between perceived safety and exe...

aim and background: complex nature of children`s affectionate problems requires assessment and usage of modern treatments. the present study aimed to investigate the effects of attachment-based therapy on depression symptoms in girl students of primary school who had attachment problems. methods and materials: this study was an empirical plan with pretest-posttest, follow up and control group. ...

Venice being an iconic example, several popular locations are de-populating as residents driven out by tourism. We address the complexity of residents' decision to stay adopting theory. The study runs a fuzzy-set qualitative comparative analysis understand impact perceived tourism benefits (economic, environmental, and socio-cultural), place attachment, length residence on intention stay. findi...

despite the close relationship between collective memory and urban structure, as the relationship between what is hidden and what is visible, rapid changes throughout the city have caused a disconnection between integrated memories and landscape cohesion. as a context for memories, the historical urban landscape proves valuable. the present research seeks to identify elements and signs in urban...

the purpose of this study was to explore the role that perceived childhood attachment, family functioning and attribution styles have in social anxiety of high school students. 430 iranian students were selected by multistage cluster sampling from high schools of isfahan city. participants completed measures of childhood attachment to each parent (hazen and shaver, 1986), the family adaptabilit...

A conceptual model for colloid transport is developed that accounts for colloid attachment straining, and exclusion. Colloid attachment and detachment is modeled using first-order rate expressions, whereas straining is described using an irreversible first-order straining term that is depth dependent. Exclusion is modeled by adjusting transport parameters for colloid-accessible pore space. Fitt...

introduction: mother as the main attachment figure has an undeniable effect on affective development of the child. the aim of the current study was to investigate the relationship and predictability of girls` attachment problems through mothers` attachment style. method: sample included 388 individuals of second and fourth grade of primary school that had been chosen through multistage cluster ...