LTHOUGH infectious mononucleosis is a benign disease, many manifestations are similar to those observed in malignant transformation of lymphocytes. Among these are generalized lymphadenopathy and hepatosplenomegaly, the occurrence of morphologically abnormal cells in the periphera! blood and occasionally in the bone marrow, associated Coombs’ positive hemolytic anemias, and abnormal protein pro...

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is diagnosed by three criteria including cutaneous drug eruption, hematologic abnormalities, and systemic involvements. The hematologic abnormalities include presence of atypical lymphocytes or eosinophilia. The systemic involvements include lymphadenopathy, hepatitis, interstitial nephritis, interstitial pneumonia, or carditis....

Mycosis Fungoides (MF) is the most common type of Cutaneous T-Cell Lymphoma (CTCL) and represents nearly 50% of all primary cutaneous lymphomas [1]. MF is characterized by an epidermotropic skin infiltrate of atypical CD4+ phenotype lymphocytes. In a minority of MF cases, the atypical infiltrate is CD8 positive. The later form of CTCL generally follows a rapid, aggressive clinical course [2]. H...

A system of 3H-thymidine incorporation by lymphocytes in culture for 3 wk has been utilized for quantitative assessment of the ability of T lymphocytes to inhibit outgrowth of autologous Epstein-Barr virus (EBV) transformed B lymphocytes. Lymphocytes from EBV-seronegative individuals lack the ability to suppress outgrowth of autologous EBV-transformed B lymphocytes. This capability appears duri...

We describe a 75-year-old Japanese woman with blastic plasmacytoid dendritic cell neoplasm. On her first visit, there were multiple areas of disseminated, elastic hard nodules with multicentric purpura on her scalp. Histopathologically, there were atypical large lymphocytes densely infiltrated through the upper dermis to subcutaneous tissue. Immunohistochemical staining revealed that these infi...

By W. J. Mrn s, L. J. BERGNA, I. B. MEDNICOFF AND WI. DAMESHEK I HE RESULTS of a number of studlies of glycogen content of the lymphocytes and related cells ( lymphoblasts, atypical lymphocytes, “lymphosarcoma” cells ) indicate that this metabolic component may have both clinical and theoretical importance. Wislocki,1 Storti,2 and, more recently, Astaldi and Verga3 observed an increase of glyco...

I T IS NOW generally agreed that the atypical mononuclear cells associated with infectious mononucleosis are members of the lymphocyte family,”2 but little is known about physiologic differences that may exist between the abnormal cells and normal lymphocytes. One approach to an understanding of such differences has been the study of nucleic acid synthesis. Using radioautographic technics, Gavo...

ous tissues of the thorax and abdomen. A biopsy specimen of his skin lesions showed nonspecific inflammatory cell infiltration of the dermis. A bone marrow biopsy specimen revealed hypercellularity with trilineage hyperplasia consistent with a peripheral destructive process. The blood smear demonstrated several atypical lymphocytes with convoluted nuclei. Cerebrospinal fluid examination re sult...

Primary pulmonary NK/T cell lymphoma is extremely rare. The authors reported a case of primary pulmonary NK/T cell lymphoma in a 47-year-old man presented with fever, cough, and chest pain. Morphologically, an angiocentric/angiodestructive growth pattern with coagulative necrosis was observed. On immunohistochemical staining, the atypical lymphocytes showed TIA-1+, CD56+, Ki-67 40%+, Cytokerati...

I T IS NOW generally agreed that the atypical mononuclear cells associated with infectious mononucleosis are members of the lymphocyte family,”2 but little is known about physiologic differences that may exist between the abnormal cells and normal lymphocytes. One approach to an understanding of such differences has been the study of nucleic acid synthesis. Using radioautographic technics, Gavo...