methods fifty-three patients who were treated at the department of gastroenterology and hepatology of the university clinic essen from 2008 to 2013 included in this retrospective study. laboratory parameters were used to calculate non-invasive markers for liver fiibrosis. every patient underwent a liver biopsy within 6 months of the liver stiffness measurement. objectives autoimmune hepatitis (...

BACKGROUND Arginase is an enzyme of the urea cycle, and one of the two isoenzymes is the liver-type enzyme. We examined serum autoantibodies to this liver-type enzyme in patients with hepatitis. METHODS Antibodies to recombinant human liver-type arginase were measured by ELISA in 95 patients and 55 healthy controls. RESULTS The mean absorbance values in the ELISA assays of patients with def...

OBJECTIVE The objective of this study was to evaluate the health-related quality of life in children and adolescents with autoimmune hepatitis. METHODS A cross-sectional assessment with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) was completed for 80 patients with autoimmune hepatitis and 45 healthy controls. Demographic data, prednisone dose, disease remission state, disease sev...

INTRODUCTION Q fever is a zoonotic infection that may cause severe hepatitis. Q-fever hepatitis has not yet been associated with autoimmune hepatitis and/or primary biliary cirrhosis. CASE PRESENTATION We describe a 39-year-old man of Sri Lankan origin with chronic Q-fever hepatitis who developed autoantibodies compatible with autoimmune hepatitis/primary biliary cirrhosis overlap syndrome. U...

autoimmune hepatitis is (aih) is a chronic hepatitis that occurs in children and adults of all ages. it is characterized by immunologic and autoimmune features, including circulating auto antibodies and high serum globulin concentrations. it was first described in the 1950s by term of chronic active hepatitis. it has 2 types with different auto antibodies. diagnosis is based upon serologic and ...

Autoimmune hepatitis is a heterogeneous liver disease of unknown etiology. It is predominant in females and characterized by elevation of transaminase, hypergammaglobulinemia and circulating autoantibodies. Interface hepatitis and plasma cell infiltration are the main findings on liver biopsy. However, deep cholestatic jaundice is rarely seen. We present here an unusual case of type 1 autoimmun...

an 11-year-old female patient with autoimmune hepatitis (aih) was referred to our rheumatology clinic due to her current musculoskeletal manifestations. the patient had been diagnosed with aih 3 months previously, based on jaundice and impaired liver function tests, and she had been treated with low-dose prednisolone and azathioprine. she presented with malaise, arthritis, a malar rash on the f...

introduction to define the clinical features, biochemical and histological findings and outcome of three forms of autoimmune hepatitis.   materials and methods in a cross sectional study between november 2001 to january 2008 in tehran and mashhad university of medical sciences, 61 children who diagnosed as aih (40 girls and 21 boys) have been analyzed for their clinical, serological, and histol...

background: the current immunosuppressive treatment of patients with autoimmune hepatitis (aih) consists of prednisolone and azathioprine. high doses of prednisolone used for disease remission are not universally effective and have serious adverse effects. some authors have provided evidence of aih therapy in children and adults with cyclosporine (neoral) should corticosteroid therapy become in...

context the pnpla3 i148m variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. the i148m variant is associated with many chronic liver diseases. however, its potential association with inflammatory and autoimmune liver diseases has not been established. evidence acquisition we systemically...