Objective(s): Calcineurin (CN) is a main phosphatase and a critical regulator of cellular pathways for learning, memory, and plasticity. The FK-506 (tacrolimus),a phosphatase inhibitor, is a fungal-derived agent and a common immune suppressant extensively used for tissue transplantation. To further clarify the role of CN in different stages oflearning and memory the main aim of this study was t...

This study investigated whether application of acute restraint stress or dexamethasone, as a glucocorticoid receptor agonist, impaired retrieval of long-term memory and if pretreatment with opiate antagonist naloxone blocked their effects on memory retrieval. Young adult male rats were trained in one trial inhibitory avoidance task (1 mA, 1.5 s foot shock). On retention test given 48 hr after t...

This study investigated whether application of acute restraint stress or dexamethasone, as a glucocorticoid receptor agonist, impaired retrieval of long-term memory and if pretreatment with opiate antagonist naloxone blocked their effects on memory retrieval. Young adult male rats were trained in one trial inhibitory avoidance task (1 mA, 1.5 s foot shock). On retention test given 48 hr after t...

BACKGROUND AND PURPOSE The purpose of this study was to investigate the behavioral changes, in particular retention of memory, after focal cerebral ischemia in rats. METHODS Ischemia was produced by permanent occlusion of the left middle cerebral artery (MCA). For quantitative behavioral analysis, one-trial passive avoidance response and active avoidance response with the discrete lever-press...

Vitamin E (vit. E) is an antioxidant compound with different kinds including tocopherols and tocotrienols. The major sources of vit. E are vegetable and seed oils. The recommended dietary allowances vary with age, gender, and state of the person. There have been numerous experiments showing beneficial effects of vit. E on immune system, cancer, and coronary artery diseases in the elderly. Moreo...

Both aging and age-associated neurodegenerative diseases are related with various degrees of behavioral impairments, and among the prime candidates responsible for producing the neuronal changes mediating these behavioral deficits, appear to be free radicals and the oxidative agents which they generate. Free radicals such as vit. E may be important factors in maintaining neuronal integrity and ...

Both aging and age-associated neurodegenerative diseases are related with various degrees of behavioral impairments, and among the prime candidates responsible for producing the neuronal changes mediating these behavioral deficits, appear to be free radicals and the oxidative agents which they generate. Free radicals such as vit. E may be important factors in maintaining neuronal integrity and ...

Vitamin E (vit. E) is an antioxidant compound with different kinds including tocopherols and tocotrienols. The major sources of vit. E are vegetable and seed oils. The recommended dietary allowances vary with age, gender, and state of the person. There have been numerous experiments showing beneficial effects of vit. E on immune system, cancer, and coronary artery diseases in the elderly. Moreo...

The present study was aimed at developing a new inhibitory avoidance task, based on training and/or testing rats in multiple contexts, to investigate accuracy of memory. In the first experiment, male Sprague-Dawley rats were given footshock in an inhibitory avoidance apparatus and, 48 h later, retention latencies of each rat were assessed in the training apparatus (Shock box) as well as in a no...

Introduction: Protein kinase M zeta (PKMζ) is assumed to be actively involved in retainig long-term potentiation. The goal of this study was to investigate the role of PKMζ in basolateral amygdala (BLA) upon acquisition, consolidation, retention and retrieval of memory using a specific inhibitor of PKMζ. Methods: Sixty male wistar rats underwent stereotaxic surgery and were cannu...