Deuterated organic molecules provide the basis for many applications in life sciences and material research. Thus, methodologies to access labeled compounds with defined selectivity continue be important. Using KOtBu as base DMSO-d6 deuterium source, we present a general applicable method selective deuteration of set nitrogen-containing heterocycles (pyridines, azines bioactive molecules). Expe...

The thermolysis of several N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-n-amines (where n = 2, 3 and 4) gives a mixture of thiazolopyridine-2-carbonitriles in low to moderate yields. Introduction, by design, of a chlorine substituent at the C2 or C4 position of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-3-amine and other selected azines enables a BnEt(3)NI mediated ANRORC style ring t...

azines, butyrophenones, or thioxanthenes. Measurement of the effect of drugs of these classes on serum prolactin levels in the rat also serves to identify dopamine receptor blockers and is much simpler (10). Of greater importance is the fact that there are many drugs of these classes already in clinical use. New drugs of the same type usually differ only quantitatively in potency, sedative effe...