BACKGROUND Understanding how growth state influences Mycobacterium tuberculosis responses to antibiotic exposure provides a window into drug action during patient chemotherapy. In this article, we describe the transcriptional programs mediated by isoniazid (INH) during the transition from log-phase to nonreplicating bacilli, from INH-sensitive to INH-tolerant bacilli respectively, using the Way...

The Prevalence of Carbapenemase Genes in Carbapenem-resistant Gram-negative Bacilli, Masih Daneshvari Hospital, Tehran, Iran, 2019-2020

The resistance of white mice to tuberculous infection could be increased by preliminary vaccination with small amounts of tubercle bacilli killed by contact with 2 per cent phenol. Vaccine prepared from a variant strain of human tubercle bacilli unable to multiply in vivo (H37Ra) proved as active as vaccines prepared from either virulent or attenuated strains. The immunity induced by phenol-kil...

Since Hansen first noted variations in the morphology of leprosy bacilli in 1895, many investigators have given attention to such morphologic variations as revealed by staIned preparations. After the advent of antileprosy drugs, many clinicians observed rapid decrease in the proportion of uniformly stained bacilli under therapy. In 1960 Ridley first proposed a "Granularity Index" based on three...

An unusual form of microbial persistence displayed by tubercle bacilli of human origin was described in previous reports from this laboratory (3-5). Relatively large populations of bacilli (one to three million cells) could be made to "vanish" uniformly from the tissues of mice that had received two compounds; the nicotinamide derivative pyrazinamide, and isoniazid, in appropriate time-dose rel...

Dear Sir,?At the present early stage of sero-diagnosis in typhoid fever perhaps this note may not be quite inopportune. Not having previously seen the method applied, I asked Dr. Srinivasa Rao, Bacteriologist to the Government of Mysore, to kindly give a demonstration in case I could find the necessary material. This Surgeon-Colonel Lang Browne very kindly supplied in the South Station Hospital...

If genetically resistant and susceptible rabbits inhale a certain number of human type tubercle bacilli, no tuberculosis in the lungs of the resistant animals is seen, as a rule several months after infection, while there is a variable and often extensive disease in the susceptible rabbits. The analogy to the presence or absence of active tuberculosis in man infected with the tubercle bacillus ...

Poor effluent management is known to release antibiotic resistance genes and heavy metal into streams. The objective of this study was investigate the occurrence antibiotics metals in hospital effluents streams Benin. extraction genomic DNA from multidrug-resistant bacterial strains isolated stream samples performed according recommendations Quick-DNA TM miniprep kit (Zymo Research Corp, United...

A spontaneous respiratory disease of mice incited by Friedländer like bacilli has been described. The bacilli inducing the disease, while morphologically and culturally indistinguishable from the usual varieties of Friedländer bacilli, are antigenically distinct from the common type strains known. The bacilli grow better in cultures at 23 degrees C. than at 37 degrees C. The disease in mice dis...

Leprosy bacilli harvested from freshly biopsied tissue from cases of lepromatous, borderline and histoid leprosy were, in conjunction with Mycobacterium lepraemurium and representative mycobacteria, examined cytochemically with and without their pyridine-extractable acid-fastness. Unlike the mycobacteria, unextracted leprosy bacilli failed to give a positive response to the periodic acid Schiff...