Presented here is the case of a nine-month-old boy with the osteomyelitis of the upper area sternum caused by bacillus Calmette-Guerin (BCG), the Danish 1331 strain vaccine against tuberculosis. Upon examination, a swelling of approximately 2×3 cm diameter was observed in the upper sternal area. The mass was hard, fixed and sensitive to palpation with no local skin hyperaemia. Chest X-rays reve...

For more than 70 years, Bacillus Calmette-Guerin (BCG) vaccines have been administered safely to billions of individuals throughout the world. Local adverse reactions following BCG vaccination usually occur at a rate of 0.1 to 0.5 per 1000 vaccinations, and serious, disseminated complications occur at a rate of less than 1 in a million vaccinations [1]. Physicians should be aware of the various...

This study examined the role of intranasal vaccination with Mycobacterium tuberculosis antigen85 complex proteins formulated in dimethyldioctadecylammonium bromide against airway Mycobacterium tuberculosis challenge in mice. Intranasal vaccination with antigen85A and antigen85B induced a significantly higher level of interferon-gamma, interleukin-12 and interleukin-4 in cervical lymph nodes tog...

Bacillus Calmette-Guerin (BCG) therapy has been proven to be effective treatment for superficial bladder carcinoma with complications that are usually minor and self limited. Although rare, granulomatous hepatitis can develop, and it is important to recognize it and treat it promptly. The hepatitis which occurs appears to be the result of a hypersensitivity reaction to antigens present in the B...

Information from comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guerin (BCG) principally allows prediction of potential vaccine candidates. Thirty-six M. tuberculosis DNA vaccine candidates identified by comparative proteome analysis were evaluated in the mouse model for protection against low-dose aerosol M. tuberculosis infection. We iden...

Despite the long history of worldwide use of bacillus Calmette-Guerin (BCG) vaccine, a wide spectrum of adverse reactions has been observed in a small proportion of immunized infants. The most severe complication is disseminated BCGitis, often fatal but extremely rare and considered to be a result of host immunodeficiency. At present, polymerase chain reaction test, CT scan, ultrasound, X-rays ...

We report a 15-month-old boy who developed an ulcer in the left axillary fold following bacillus Calmette-Guerin vaccination. Subsequent immunologic and genetic studies led to the diagnosis of chronic granulomatous disease. His mother had "lupus-like" lesions, described in some carriers of this disease, that were thus related to her son's diagnosis. Although in healthy subjects this vaccination...

Objective: This study was aimed at screening differentially expressed genes (DEGs) and exploring the potential immune mechanism induced by Bacillus Calmette-Guerin (BCG) vaccine in a humanized mouse model. Methods: Candidate DEGs between mice vaccinated with BCG or injected PBS were identified through transcriptomics, their biological functions, signaling pathways, protein interaction networks ...