Background: β-thalassemia is one of the most widespread disease in the world, including Iran. In this study, we reported, for the first time, A 290-bp β-globin gene deletion in the south of Iran. Methods: Four individuals from three unrelated families with Arabic ethnic background were studied in Khuzestan Province. Red blood cell indices and hemoglobin analysis were carried out accor...

nEXO is a proposed experiment that will search for neutrinoless double-beta decay (0$\nu\beta\beta$) in 5-tonnes of liquid xenon (LXe), isotopically enriched $^{136}$Xe. A technique called Ba-tagging being developed as potential future upgrade to detect the $^{136}$Xe daughter isotope, $^{136}$Ba. An efficient has boost nEXO's 0$\nu\beta\beta$ sensitivity by essentially suppressing non-double-b...

Particle tracks and differential energy loss measured in high pressure gaseous detectors can be exploited for event identification neutrinoless double beta decay~($0\nu \beta \beta$) searches. We develop a new method based on Kalman Filter Bayesian formalism (KFB) to reconstruct meandering of MeV-scale electrons. With simulation data, we compare the signal background discrimination power KFB as...

The prevalence of Klebsiella pneumoniae coproducing carbapenemase metallo-β-lactamase 1 (NDM-1) and OXA-48 has been increasing globally since 2013. The complete genome of KP617 was sequenced and assembled into a circular chromosome and two plasmids. This sequence provides the genetic background for understanding the evolution of carbapenemase genes in K. pneumoniae KP617.

Klebsiella pneumoniaeisolates that produce carbapenemases (KPCs) are rapidly disseminating worldwide. To determine their genetic background, we investigated 16 blaKPC-2-harboring K. pneumoniae isolates from 5 countries. The isolates were multidrug resistant, possessed the blaKPC-2 gene, and differed by additional Beta-lactamase content. They harbored a naturally chromosome-encoded bla gene (bla...

Since most archaea are extremophilic and difficult to cultivate, our current knowledge of their biology is confined largely to comparative genomics and biochemistry. Haloferax volcanii offers great promise as a model organism for archaeal genetics, but until now there has been a lack of a wide variety of selectable markers for this organism. We describe here isolation of H. volcanii leuB and tr...

Background and Objective: Beta-2 Microglobulin (β2M) is a middle molecular weight uremic toxin. Lack of β2M removal leads to β2M accumulation and amyloidosis in hemodialysis patients. The present research aims to determine the relationship between β2M and inflammatory factors, such as C-reactive protein (CRP), albumin, and high-density lipoprotein (HDL) in hemodialysis patie...