BACKGROUND Endophytes, which reside in plant tissues, have the potential to produce novel metabolites with immense benefits for health industry. Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell were investigated. METHODS Endophytic fungi were isolated from the Bacopa monnieri. Extracts from liquid cultures were tested for cytotoxicity again...

In this study, we have chosen HPTLC as a method of analysis to develop a standard procedure based on fingerprinting characteristics for the evaluation of homoeopathic formulations. A simple and accurate HPTLC method has been developed for the quantification of BacosideA and fingerprinting of the in-house mother tincture considered here to be a standard with that of different marketed samples av...

BACKGROUND The current therapy of neuropathic pain is inadequate and is limited by the extent of pain relief and the occurrence of dose dependant side effects. Insufficient control of pain with conventional medications prompts the use of complementary and alternative medicine therapies by patients with neuropathic pain. This study therefore investigated a standardized methanolic extract of Baco...

Implementation period CDRI was established in 1951 and has pursued various broad-based and long-term drug development projects over the ensuing five decades.This approach has led to the development of a pipeline of products from natural resources, including the commercialization of at least five lead compounds or products: gugulipid (hypolipidaemic), Bacopa monniera standardized fraction (memor...

Brahmi (Bacopa monnieri) has been used by Ayurvedic medical practitioners in India for almost 3000 years. The pharmacological properties of Bacopa monnieri were studied extensively and the activities were attributed mainly due to the presence of characteristic saponins called "bacosides." Bacosides are complex mixture of structurally closely related compounds, glycosides of either jujubogenin o...

The levels of malondialdehyde and lipofuscin pigments were increased in the prostate of D-galactose (0.5 ml/day, sc, for 20 days) induced aging mice. After B. monniera (40 mg/kg body weight for 20 days) ethanol leaf extract administration levels of both the parameters were reduced significantly. The results suggest that B. monniera prevents formation of malondialdehyde and lipofuscin pigments w...

Nausea and vomiting are the most distressing and common side effects of cancer chemotherapy which often result in patient non-compliance. In the present study, standardized methanolic fractions of Bacopa monniera (BM) were evaluated against cisplatin induced emesis in the pigeon in relation to their activity on central and intestinal neurotransmitter levels. Cisplatin (7.0 mg/kg, i.v.) induced ...

AIM Earlier studies have demonstrated that Bacopa monniera (BM), a plant described in Ayurveda for many CNS actions was found to exhibit antidepressant (methanolic extract at 20mg/kg and 40mg/kg p.o.) as well as antinociceptive activity (aqueous extract (AE) at 80 mg/kg, 120 mg/kg and 160 mg/kg p.o.). The present study sought to explore the possible mechanisms of antinociceptive effects of aque...

Bacopa monnieri is a well known herb for its use in enhancing memory and in treatment of epileptic disorders ever since from ancient times. While effects of hydro-methanolic extracts of Bacopa monnieri on isolated heart has not been reported yet, so in this present study we aim to investigate effect of 75% hydromethanolic extract of Bacopa monnieri on isolated frog heart and cytotoxic activity ...

Chronic pains management costs billions of dollars in medical exchequer to the world population. Additionally, 77% of people with chronic pains also have a degree of medically treatable depression. Opioids have a narrower safety index due to their side effects associated with its tolerance, hyperalgesia and subsequent dependence. Likewise, non steroidal anti-inflammatory drugs and anticonvulsan...