objective(s) cannabinoids have been implicated in memory deficit. we examined the effect of am281, cannabinoid antagonist/inverse agonist in prevention of scopolamine-induced cognitive deficit. materials and methods  object recognition task was used to evaluate memory in mice. exploration time in the first and the second trial was recorded. the differences in exploration between a previously se...

OBJECTIVES The use of TNF-alpha antagonists may be associated with an increased rate of infections in risk populations of patients with RA. Our hypothesis was that in patients with a high risk of infection Rituximab (RTX) could be a safer alternative. METHODS We analyzed the outcome of RA patients who received RTX instead of TNF-alpha antagonist because of a history of serious infections or f...

Bacterial populations co-ordinate gene expression collectively through quorum sensing (QS), a cell-to-cell communication mechanism employing diffusible signal molecules. The LysR-type transcriptional regulator (LTTR) protein PqsR (MvfR) is a key component of alkyl-quinolone (AQ)-dependent QS in Pseudomonas aeruginosa. PqsR is activated by 2-alkyl-4-quinolones including the Pseudomonas quinolone...

Research of the biocide action streptomycete-antagonist metabolites on causative agent bacterial canker tomato and host-plant fertility is actual question. Aim. To determine Streptomyces globisporus 3-1 cyanogenus S136 phytopathogen Clavibacter michiganensis 102 in vitro seed germination, growth yield tomatoes vivo. Methods. Microbiological methods laboratory conditions descriptive-comparative ...

Hypertension is a serious health problem due to high frequency and concomitant other diseases including cardiovascular and renal dysfunction. Olmesartan cilexetil is a new antihypertensive drug associated with angiotensin II receptor antagonist. This study was conducted to evaluate the mutagenicity of olmesartan cilexetil by bacterial reverse mutation test using Salmonella typhimurium (TA100, T...

Neutrophils are key effector cells of the innate immune response to pathogenic bacteria, but excessive neutrophilic inflammation can be associated with bystander tissue damage. The mechanisms responsible for neutrophil recruitment to the lungs during bacterial pneumonia are poorly defined. In this study, we focus on the potential role of the major high-affinity thrombin receptor, proteinase-act...

BACKGROUND COPD is emerging as the third largest cause of human mortality worldwide after heart disease and stroke. Tobacco smoking, the primary risk factor for the development of COPD, induces increased expression of platelet-activating factor receptor (PAFr) in the lung epithelium. Nontypeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae adhere to PAFr on the luminal surface of ...

PurposeInduction immunosuppression in heart transplant (OHTX) recipients varies greatly by center. Roughly 50% receive induction and no regimen has been shown to improve survival. Basiliximab (BAS) is an IL-2 receptor antagonist used as OHTX. The objective of this retrospective study was compare rejection, infection, mortality within the first-year following patients who received BAS or steroid...

background and objectives:infection of pleural fluid is a common disease and because of antibiotic administration, the microbiology of this fluid has changed. the aim of this study was to determine the common bacteria and suitable antibiotics for treatment in pleural effusion (pe). materials and methods: in this cross sectional study, 1210 samples with exudative features were cultured for poss...