Background: Neonatal sepsis is a generalized bacterial infection which occurs in the first month of life. Intraventricular hemorrhage is the most common intracerebral disorder which occurs in premature neonates. Mean Platelet Volume (MPV) is considered as a marker of intraventricular hemorrhage (IVH) in some studies. The aim of this study was to evaluate the impact of MPV on IVH and sepsis in n...

Severe bacterial sepsis leads to a proinflammatory condition that can manifest as septic shock, multiple organ failure, and death. Neutrophils are critical for the rapid elimination of bacteria; however, the role of neutrophil chemoattractant CXCL1 in bacterial clearance during sepsis remains elusive. To test the hypothesis that CXCL1 is critical to host defense during sepsis, we used CXCL1-def...

Sepsis is a fast progressing disease, triggered by the host response to infection. If untreated, sepsis can rapidly evolve to multi-organ dysfunction and septic shock [1]. Despite numerous advances in palliative intensive care and antibiotic treatment, sepsis remains a major cause of morbidity and mortality [2]. The lack of effective therapies making it to market is due to our poor understandin...

Bacterial sepsis is an important cause of morbidity and mortality in patients with HIV. HIV causes increased susceptibility to invasive infections and affects sepsis pathogenesis caused by pre-existing activation and exhaustion of the immune system. We review the effect of HIV on different components of immune responses implicated in bacterial sepsis, and possible mechanisms underlying the incr...

Introduction: The use of Procalcitonin (PCT) as a bacterial diagnostic marker is controversial in patients on hemodialysis (HD). Infections account for considerable morbidity and mortality in patients on HD. Hence, early diagnosis of bacterial infections is important to make a prognostic assessment of its severity. If PCT can be used as a primary marker for bacterial infections in patients on H...

Introduction Early diagnosis of sepsis is the key for improving the survival, therefore biomarkers have an important place in this process because they can indicate the presence or absence of sepsis [1]. Procalcitonin aids in diagnosis and risk stratification of bacterial sepsis [2].Using pro-BNP as inflammatory marker in diagnosing severe sepsis and septic shock is based on cytokines productio...

Family medicine physicians will encounter severe sepsis. Normally the work-up consists of searching for the bacterial source and then modifying initial empiric treatment. Unfortunately, not all infectious sources of sepsis are bacterial; 7% of sepsis cases seen are due to a virus, fungi, or protozoa. Presented here is a case of an otherwise healthy adult female with severe sepsis, negative bloo...

D IFFERENTIATING BACTERIAL SEPSIS FROM other conditions common in infants in the neonatal intensive care unit poses a number of challenges. First, clinical signs such as apnea, feeding intolerance, and need for increased respiratory support are nonspecific but still of concern for bacterial sepsis. These signs often prompt evaluation for sepsis that includes blood culture and antibiotic therapy...

Background. Bacterial sepsis is a major cause of illness in human immunodeficiency virus infected patients. There is scarce evidence about sepsis among HIV patients in Ethiopia. This study aimed to determine the etiologic agents of bacterial sepsis and their antibiotic susceptibility patterns among HIV infected patients. Methods. A cross-sectional study was carried out from March 1 to May 2, 20...