Infectious diseases remain a major cause of deaths and disabilities in the world, the majority of which are caused by bacteria. Although immunisation is the most cost effective and efficient means to control microbial diseases, vaccines are not yet available to prevent many major bacterial infections. Examples include dysentery (shigellosis), gonorrhoea, trachoma, gastric ulcers and cancer (Hel...

AIM Brucellosis is a major bacterial zoonosis of global importance affecting a range of animal species and man worldwide. It has economic, public health, and bio-risk importance. Control and prevention of animal brucellosis mainly depend on accurate diagnostic tools and implementation of effective and safe animal vaccination program. There are three types of animal Brucella live vaccines - Bruc...

Hospital-acquired infections are one of the main challenges and concerns of patients and medical staff in hospitals and healthcare centers. Meanwhile, Clostridium difficile infection is one of the most important bacterial hospital infections. Prevention is the best and most effective way to deal with these infections. Designing and using vaccines against these infectious microorganisms is the b...

Antibody production and clinical efficacy (relative percent survival RPS) were measured in 40±5g rainbow trout after immunization with two types of Streptococcus iniae vaccines consisting of formalin killed cells (FKC) and FKC enriched with the bacterial extracellular products (ECP) administered by intraperitoneal (i.p), immersion and oral routes at 16±1°C for 18 weeks. No significant differenc...

Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old, Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis being the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more rec...

mucosal surfaces of the body provide a universal entry portal for all known and emerging infectious pathogenic microbes. therefore, it seems that special vaccination strategies are needed for vaccines that can hinder the entry capability of pathogenic microbes through the mucosal surfaces. lactic acid bacteria are widely used in the food industry and are presently applied as delivery vehicles i...

Methods: A field trial was conducted on one group of nursery pigs (N=330). Pigs were randomly allocated to one of four groups that each received one of the following treatments at weaning: an experimental autogenous vaccine administered intramuscularly (IM) (n = 90); a standard autogenous vaccine administered IM (n = 90); a commercial bacterin, administered intraperitoneally (IP) (n = 60); or n...

not correct and gives a false idea regarding the protective power of the vaccine. In fact, none of the dead bacterial vaccines could be relied upon to give absolute protection against an overwhelming infection and the same is true of plague vaccine. However, recently some public health officers and medical men in the province working in the field have doubted as to whether it is of any value at...

Many vaccines have been developed from live attenuated forms of bacterial pathogens or from killed bacterial cells. However, an increased awareness of the potential for transient side-effects following vaccination has prompted an increased emphasis on the use of sub-unit vaccines, rather than those based on whole bacterial cells. The identification of vaccine sub-units is often a lengthy proces...

I nactivated vaccines now are commonly-used tools to stimulate the immune systems of layers and breeders. For viral antigens, inactivated vaccines are used primarily to induce a prolonged antibody response in birds which have previously received live virus vaccines. For bacterial antigens, these vaccines are typically used in birds which have not previously been vaccinated with a live bacterial...