Personalized nutrition is emerging as a promising approach to optimize health outcomes by accounting for individual genetic and metabolic differences. This review examines the current methods approaches integrating genetics metabolomics into personalized strategies. We discuss importance of understanding an individual's makeup, including single nucleotide polymorphisms (SNPs), their effects on ...

TheAmerican Institute of Nutrition held a seminar in 1994 entitled ‘Dietary Nucleotides: A recently demonstrated requirement for cellular development and immune function’. The purpose of the symposium was to consider research that had been accumulating over the previous two decades, suggesting that under certain circumstances dietary nucleotides were ‘semi-essential’ dietary requirements for hu...

Methods Retrospective analysis on hospital stays’ database in the pediatric unit at Hopital Principal de Dakar between September and November 2010. Patients with a positive bacteriological test were selected. Probable cases of HCAI were included on clinical and bacteriological data (presence of multiresistant bacteria). Cases were matched to control patients (with no infection) by sex, age and ...

Both reduced DNA repair capacity (DRC) and folate deficiency are associated with increased cancer risk. Furthermore, folate is involved in DNA repair through de novo DNA synthesis and methylation. To determine whether low dietary folate intake is associated with low cellular DRC in humans, we assessed total dietary folate intake using a food frequency questionnaire in 559 non-Hispanic white can...

BACKGROUND Teicoplanin is a glycopeptide antibiotic that has been used to treat serious, invasive infections caused by Gram-positive bacteria. The area under the drug concentration-time curve (AUC)/minimum inhibitory concentration (MIC) was identified as a pharmacokinetic-pharmacodynamic (PK-PD) parameter of glycopeptide antibiotics that correlated with bacteriological responses and clinical ou...

efficacy; whereas in the patients treated with penicillin V, no differences would be found with respect to bacteriological (P = 1.0) and clinical efficacy (P = 1.0) between patients with a clarithromycin-susceptible strain and those with a clarithromycin-resistant strain. In the PP analysis of the group treated with clarithromycin, clinical cure at visit three was obtained in 95.2% (120 of 126)...

The aim of the present study was to investigate the influence of dietary nucleotides on liver morphology. Adult rats were fed for 21 d on a nucleotide-containing diet or the same diet free of nucleotides. Liver sections were examined by light and transmission electron microscopy, as well as for nucleic acid and protein contents. Morphometric analysis was performed for different variables. Depri...

the importance of dietary fiber in normal and therapeutic diets has been acknowledged by numerous authors in recent years. dietary fiber has different physiological effects on human health. the recommended daily intake of dietary fiber is about 30 g, but less than this is often consumed. wheat bran is an excellent source of dietary fiber and is used to fortify foods. the nutritional benefits of...