نتایج جستجو برای: bad gene
تعداد نتایج: 1170207 فیلتر نتایج به سال:
In every medical specialty bad, sad, and difficult information must be given to patients and their families. An insensitive approach increases the distress of recipients of bad news, may exert a lasting impact on their ability to adapt and adjust, and can lead to anger and an increased risk of litigation. Many doctors also find these interactions stressful, and in the absence of much effective ...
BAD, a proapoptotic molecule of the BCL2 family, is regulated by reversible phosphorylation. During survival, BAD is sequestered by 14-3-3 through serine 136 phosphorylation and is dissociated from BCL-X(L) through serine 155 phosphorylation. We report that phosphoserine 112 (pSer112) dephosphorylation functions as a gatekeeper for BAD-mediated apoptosis. During apoptosis, dephosphorylation of ...
Karl Popper discussed admirably the choice between faith and reason [Popper, 1945, Ch. 24]. He admitted that the basis of rationalism is a faith of sorts, a faith in reason. Later on his disciple William W. Bartley dissented from him [Bartley, 1962] and even called him a fideist [Radnitzky and Bartley, 1987, 205, 208, 210-11], much to his annoyance. All this caused bad blood between the two [La...
The precise mechanisms by which Abl oncogenes transform hematopoietic cells are unknown. We have examined the role of Pim kinases in v-Abl-mediated transformation. In v-Abl transformants, expression of Pim-1 and Pim-2, but not Pim-3, is dependent on Abl kinase activity. Transformation assays demonstrate that v-Abl cannot efficiently transform bone marrow cells derived from Pim-1(-/-)/Pim-2(-/-)...
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