Electrolyte disturbances in leukemia can be the result of the disease process or drug therapy. One group of electrolyte abnormalities is related to the stage of the leukemic process. Included in this group are newly diagnosed patients who may show elevated serum potassium, phosphorus, and magnesium--a result of their release from malignant cells after cytotoxic therapy or their accumulation due...

The prevalence of metabolic acidosis increases in Chronic Kidney Disease (CKD) patients ac‐ cording to the fall in glomerular filtration rate (GFR). In early stages of renal dysfunction acid retention is mainly due to the reduced tubular ammonium (NH4+) secretion. As GFR de‐ clines retention of organic acids (HSO4, HPO4) is also observed. The acid load resultant from diet and protein catabolism...

From the Department of Internal Medi­ cine, St. Elisabeth Hospital, Willemstad, Curaçao (K.B.); and the Division of Ne­ phrol ogy, Depart ment of Medicine, Leiden University Med ical Center, and Leiden University, Leiden (A.P.J.V.), and the De­ partment of Internal Medicine, Uni ver sity of Groningen, University Medical Cen ter Groningen, Groningen (R.O.B.G.) — both in the Netherlands. Address ...

The main objective of applying robust active control to base-isolated structures is to protect them in the event of an earthquake. Taking advantage of discontinuous control theory, a static discontinuous active control is developed using as a feedback only the measure of the velocity at the base. Moreover, due to that in many engineering applications, accelerometers are the only devices that pr...

1. Carbon dioxide titration curves were determined in vivo in dog and man at various degrees of acute non-respiratory acidaemia and alkalaemia. 2. The slope of the CO2 titration curve (delta log Pco2/delta pH) was found to increase with the severity of the acute non-respiratory alkalaemia the slope (delta log Pco2/delta pH) tended towards unity. 3. A simple scheme based on the CO2 titration cur...

Disruption of normal gastrointestinal function as a result of infection, hereditary or acquired diseases, or complications of surgical procedures uncovers its important role in acid-base homeostasis. Metabolic acidosis or alkalosis may occur, depending on the nature and volume of the unregulated losses that occur. Investigation into the specific pathophysiology of gastrointestinal disorders has...

We undertook the present study to examine the acid-base and electrolyte disturbances in relation to hydration status in patients with diabetic ketoacidosis (DKA). A total of 40 insulin-dependent diabetes mellitus patients (22 male, 18 female), aged 18-61 years with DKA admitted to our hospital during the last 2 years, were studied. The duration of diabetes averaged 9 +/- 2 years. In all cases a...

Carp (Cyprinus carpio) were exposed to environmental water pH (pHw) step changes from 7.4 to 5.1, 5.1 to 4.0 and 4.0 to 3.5 pH, PCO2, PO2 and lactate in dorsal aortic blood, [Na+], [K+] and [Cl-] in dorsal aortic plasma, base loss, and ammonia excretion were determined as a function of time after each pHw step change. At pHw 5.1 the measured blood acid-base and electrolyte parameters remained e...

Nephrotoxicity is the most common and clinically significant adverse effect of calcineurin inhibitors. Cyclosporine and tacrolimus nephrotoxicity is manifested by both acute azotemia and chronic progressive renal disease and tubular zdysfunction. An elevation in the plasma potassium concentration due to reduced efficiency of urinary potassium excretion is common in cyclosporine-treated patients...

From the Department of Internal Medi­ cine, St. Elisabeth Hospital, Willemstad, Curaçao (K.B.); and the Division of Ne­ phrol ogy, Depart ment of Medicine, Leiden University Med ical Center, and Leiden University, Leiden (A.P.J.V.), and the De­ partment of Internal Medicine, Uni ver sity of Groningen, University Medical Cen ter Groningen, Groningen (R.O.B.G.) — both in the Netherlands. Address ...