Diurnal fluctuation of intraocular pressure (IOP) is an important issue in managing glaucoma, yet its bases are not well understood. Delineating the genetic controllers and physiological pathways may open the door to potential therapeutic targets. Miller and associates have provided evidence for a GPR18 role in the diurnal regulation of IOP in mice and explored the related endocannabinoid pathw...

In 20 unanesthetized sheep, we measured lung lymph flow and lymph and plasma protein concentrations during steady-state base-line conditions and during steady-state elevations of pulmonary microvascular hydrostatic pressure (range 3 to 23 cm H2O). In every sheep there was a base-line lung lymph flow (average 5.7 +/- 2.5 (SD) ml/hour), demonstrating that net fluid filtration occurred. The base-l...

Direct numerical simulationhas been carried out for turbulent  owovera rectangular trailing edge at aReynolds number of 1 £ £ 103 (based on the freestream quantities and the trailing-edge thickness) and ratio of boundarylayer displacement thickness to trailing-edge thickness close to unity. Two types of  ow control were studied: base transpiration and secondary splitter plate. Simulation of b...