OBJECTIVE: The purpose of the study was to examine use of the Modified Checklist for Autism in Toddlers (M-CHAT) as an autismspecific screening instrument in a large, geographically diverse pediatrics-based sample. METHODS: The M-CHATand the M-CHAT Follow-Up (M-CHAT/F) were used to screen 18 989 toddlers at pediatric well-child visits in 2 US geographic regions. Pediatricians directly referred ...

We present a conversation analysis of openings sequences of online text-based chat counseling. Particular about this chat counseling is that the clients made available their help question through pre-screening. The data consisted of 40 chat sessions with pre-screening and 34 sessions without pre-screening from the Dutch alcohol and drugs chat service. In the chat sessions with pre-screening, th...

Recent reports have brought back the acetylcholine synthesizing enzyme, choline acetyltransferase in the mainstream research in dementia and the cholinergic anti-inflammatory pathway. Here we report, a specific strategy for the design of novel ChAT ligands based on molecular docking, Hologram Quantitative Structure Activity Relationship (HQSAR) and lead optimization. Molecular docking was perfo...

In this article, we address the problem of confusion and co-text-loss in chat communication, identify requirements for a solution, discuss related work and present a new approach for addressing co-text loss in text-based chats. We report about first experiences with our solution and give an outlook on future work directions. The core idea of our solution MuViChat (multiple-visualization chat) i...

The rising use of synchronous text-based computer-mediated communication (CMC) such as chat rooms and instant messaging in government agencies and the business world presents a potential risk to these organizations. There are no current methods for visualizing or analyzing these persistent conversations to detect deception. Speech act profiling is a method for analyzing and visualizing online c...

Web-based live-chat support services are one promising means toward improving customer service. However, such services and their success factors have been rarely studied. This study bridges this gap. It builds on justice and service marketing theories, and examines key factors that drive intentions to continue using web-based live-chat support services and to provide positive word-of-mouth. The...

During the last years chat based instant messaging has become a part of the normal communication culture. Instant messaging based chat is now rapidly becoming a mainstream communication medium even in business environments. The same is becoming true for Voice over IP enabled audio communication. Skype, a high quality VoIP software has been downloaded over 200 million times and internet provider...

The focus of this paper is to investigate the possibility of predicting several user and message attributes in text-based, real-time, online messaging services. For this purpose, a large collection of chat messages is examined. The applicability of various supervised classification techniques for extracting information from the chat messages is evaluated. Two competing models are used for defin...

We investigated the effect of augmenting a chat-based learning system, with a lowand high-quality video link, on the focus (factual vs. abstract) of a case-based learning discussion. Efficient learning with cases requires discussion on the case as well as on the meaning of abstract knowledge. We find that students who first experience chat + high-quality video, focus significantly more on abstr...