Noninvasive imaging of differences between the molecular properties of cancer and normal tissue has the potential to enhance the detection of tumors. Because overexpression of endogenous transferrin receptor (TfR) has been qualitatively described for various cancers and is presumably due to malignant transformation of cells, TfR may represent a suitable target for application of molecular imagi...

AIM Transferrin receptor (TfR) has been used as a target for the molecular cancer therapy due to its higher expression in a variety of tumors. Anti-TfR antibodies combined with chemotherapeutic drugs has showed great potential as a possible cancer therapeutic strategy. In our study, we investigated the anti-tumor effects of anti-TfR monoclonal antibody (mAb) alone or in combination with curcumi...

We describe a Bayesian projection model to produce country-specific projections of the total fertility rate (TFR) for all countries. The model decomposes the evolution of TFR into three phases: pre-transition high fertility, the fertility transition, and post-transition low fertility. The model for the fertility decline builds on the United Nations Population Division's current deterministic pr...

Modern radar signals mostly use low probability of intercept (LPI) waveforms, which have short pulses in the time domain, multicomponent properties, frequency hopping, combined modulation waveforms and other characteristics, making detection estimation LPI extremely difficult, leading to highly required significant research on perception technology battlefield environment. This paper proposes a...

Heart sounds and murmurs are time-varying signals that would best be analyzed using time-frequency analysis. Windowed Wigner-Ville distribution (WWVD) and smooth windowed Wigner-Ville distribution (SWWVD) are used to obtain the timefiequency representation (TFR) of the signal. Determination of parameter setting of WWVD and SWWVD will eliminate the cross-terms and improve TFR. The accuracy of TF...

Antibodies to transferrin receptor (TfR) have potential use for therapeutic entry into the brain. We have shown that bispecific antibodies against TfR and β-secretase (BACE1 [β-amyloid cleaving enzyme-1]) traverse the blood-brain barrier (BBB) and effectively reduce brain amyloid β levels. We found that optimizing anti-TfR affinity improves brain exposure and BACE1 inhibition. Here we probe the...

OBJECTIVE Serum levels of the soluble transferrin receptor (sTfR) vary depending on the erythropoietic activity and iron status. In vitro, sTfR shed in the incubation medium correlates well with cellular TfR, but this relationship has never been established in vivo. To determine the value of serum sTfR as a quantitative marker of the body mass of tissue TfR, we designed experiments to examine t...

The measurement algorithms applied in power quality measurement systems are based on Fast Fourier Transformation. That one-dimension frequency analysis is sufficient in many cases. However, to illustrate the character of the signal in a more comprehensive manner, it is crucial to represent the investigated signal on time-frequency plane. There are a lot of time-frequency representations (TFR) f...

BACKGROUND AND OBJECTIVES Transferrin receptor (TfR) expression in erythroid cells is regulated by a number of factors, including iron status and erythropoietin (Epo) stimulation. However, the impact of these factors on reticulocyte TfR expression in vivo has never been studied. A soluble form of TfR (sTfR) is present in serum in proportion to the mass of cellular TfR. Although sTfR shedding by...

BACKGROUND Female smoking prevalence is dramatically lower in developing countries (3.1%) than developed countries (17.2%), whereas male smoking is similar (32% vs 30.1%). Low female smoking has been linked to high gender inequality. Alternatively, to protect their offspring from teratogenic substances, pregnant and lactating women appear to have evolved aversions to toxic plant substances like...