Mycophenolic acid is a secondary extracellular metabolite of Penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. The aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by Penicillium brevi-compactum ATCC16024 was investigated. Batch submerged fer...

Mycophenolic acid is a secondary extracellular metabolite of Penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. The aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by Penicillium brevi-compactum ATCC16024 was investigated. Batch submerged fer...

The present study deals with the batch and fed-batch mass production of Steinernema carpocapsae. S. carpocapsae is an entomoparasitic nematode that is used as a biological control agent of soil-borne crop insect pests. The ability and efficiency of fed-batch culture process was successful through the utilization of the nematode’s bacterial symbiont Xenorhabdus nematophila. Results from the fed-...

The growth kinetics of Aspergillus nidulans, Mucor hiemalis and Penicillium chrysogenum on solid media and in submerged culture were studied. Growth of A. nidulans colonies on solid medium can be divided into the four phases of lag, exponential, deceleration and constant growth rate. The growth kinetics of A. nidulans in submerged culture were similar to those commonly found for unicellular mic...

Performance of Cordyceps militaris mutant obtained by high-energy ion beam irradiation regarding anti-cancer agent cordycepin production in submerged culture was investigated. It was established that the mutant renders a higher production performance in surface liquid culture, needs to observe its performance in submerged culture. Two kinds of media were used for submerged culture comprising a ...

This paper presents a comparison between batch and three different sets of fed batch fermentations forrhamnolipid production by Pseudomonas aeruginosa. The batch run was performed with 500 ml of culturemedium having the initial glycerol and sodium nitrate concentrations of 30 and 8.3 g/l, respectively. For a fedbatch run with nitrogen source in feed, 250 ml of the nitrogen exc...

background and objective: sorbitol is a non-toxic and slightly hygroscopic compound with different applications. zymomonas mobiles produces sorbitol from sucrose or mixtures of glucose and fructose (formation is coupled with the dehydrogenation of glucose to glucono-δ- lactone). recombinant zymomonas mobilis may produce sorbitol and gluconic acid from glucose and fructose using different divale...

Concept Design and optimization of cell culture processes requires intensive studies based on “Design of experiments”-strategies. In academia teaching of DoE-concepts is often insufficient, as in most cases only simple culture strategies (batch) can be performed, as time and money are limited. More complex tasks such as feeding strategies for fed batch culture can be discussed theoretically onl...

AIMS The effect of synthetic media on the submerged mycelial growth and exo-biopolymer production in various edible mushrooms was investigated in shake flask culture. METHODS AND RESULTS Among 19 mushrooms examined, the relatively high yield in mycelial biomass and exo-biopolymer production was achieved in potato malt peptone (PMP) medium. In particular, Ganoderma lucidum NO. 1 and Phellinus ...