In addition to the two monomer subunits of chicken brain-type creatine kinase (B-CK, EC, 2.7.3.2), termed Bb (basic) and Ba (acidic), another subspecies called Bb* was identified by chromatofocussing in the presence of 8 M urea (Quest et al., ). The latter low abundance protein species, isolated from tissue extracts, comigrated on 2D-gels with three minor species (Bb1-3), initially identified i...

A preclinical study demonstrated anti-proliferative and apoptotic effect of propranolol on multiple myeloma (MM) cell. Clinical studies suggested that beta-blocker (BB) might impact the prognosis of breast, prostate, colorectal, ovarian, lung, and skin cancer. This retrospective study evaluated the effect of BB in MM disease-specific survival (DSS) and overall survival (OS). Among 1,971 newly d...

OBJECTIVES The risk of developing Lyme borreliosis (LB) from Borrelia burgdorferi sensu lato (Bb)-infected ticks in Sweden is largely unknown. In the current study, we investigated the prevalence of Bb in ticks that had bitten humans and the risk of developing LB from Bb-infected ticks. METHODS Health questionnaires, blood samples, and ticks were collected from 394 tick-bitten study subjects ...

OBJECTIVES This study aimed to assess the effect of re-etching of desensitized dentin for five and 10 seconds on marginal microleakage of composite restorations. MATERIALS AND METHODS Class V cavities (4×2×2mm) were prepared on the buccal surfaces of 64 third molars and randomly divided into four groups of 16. In the control group, Single Bond (SB) adhesive was applied after etching. In BB+SB...

Congenitally lymphopenic diabetes-prone (DP) BioBreeding (BB) rats develop spontaneous T cell-dependent autoimmunity. Coisogenic diabetes-resistant (DR) BB rats are not lymphopenic and are free of spontaneous autoimmune disease, but become diabetic in response to depletion of RT6+ T cells. The basis for the predisposition to autoimmunity in BB rats is unknown. Abnormal T cell development in DP-...

Intestinal neutral NaCl absorption, which is made up of brush-border (BB) Na+/H+exchange linked to BB Cl-/[Formula: see text]exchange, is up- and downregulated as part of digestion and diarrheal diseases. Glucocorticoids stimulate ileal NaCl absorption and BB Na+/H+exchange. Intestinal BB contains two Na+/H+exchanger isoforms, NHE2 and NHE3, but their relative roles in rabbit ileal BB Na+/H+exc...

OBJECTIVE : To investigate whether vitamin D receptor gene (VDR) BsmI-rs1544410 and FokI-rs2228570 polymorphisms, smoking duration, and body mass index (BMI) are risk factors for cutaneous melanoma, especially metastatic melanoma. METHODS : We studied 120 cutaneous melanoma cases [68 stage I and II non-metastatic melanoma (NMetM) patients, plus 52 Stage III and IV metastatic melanoma (MetM) p...

This experimental study investigates the possible protective effects of Gum Arabic (GA) and its nanoparticles in hepato- reno-toxicity induced by bromobenzene (BB) rats mechanisms action. Thirty-five adult male albino were sorted into following: Group 1 (control), 2 (NPs), 3 (GA, received ml/kg 10%w/v aqueous suspension), 4 (Gum-NPs, GA loaded NPs), 5 (BB), 460 mg/kg, 6 (GA+BB) 7 (GA-NPs+BB). T...

Ensuring building-block (BB) mixing is critical to the success of genetic and evolutionary algorithms. This study develops facetwise models to predict the BB mixing time and the population sizing dictated by BB mixing for single-point crossover. Empirical results are used to validate these models. The population-sizing model suggests that for moderate-to-large problems, BB mixing—instead of BB ...