The role of uptake transporter (organic anion-transporting polypeptide [Oatp]) in the disposition of a P-glycoprotein (P-gp) substrate (digoxin) at the barriers of central nervous system, namely, the blood-brain barrier (BBB), blood-spinal cord barrier (BSCB), and brain-cerebrospinal fluid barrier (BCSFB), was studied using rat as a preclinical species. In vivo chemical inhibition of P-gp and O...

Despite aggressive treatment with radiation and chemotherapy, recurrence of glioblastoma multiforme (GBM) is inevitable. The objective of this study was to show that the blood-brain barrier (BBB), through a combination of tight junctions and active efflux transporters in the brain microvasculature, can significantly restrict delivery of molecularly targeted agents to invasive glioma cells. Tran...

1. The blood-brain barrier (BBB) contributes to brain homeostastis and fulfills a protective function by controlling the access of solutes and toxic substances to the central nervous system (CNS). The efflux transporter P-glycoprotein (P-gp) is a key element of the molecular machinery that confers special permeability properties to the BBB. 2. P-gp, which was initially recognized for its abilit...

In vitro blood–brain barrier (BBB) models are essential research tools for use in developing brain-targeted drugs and understanding the physiological pathophysiological functions of BBB. To develop BBB with better functionalities, three-dimensional (3D) culture methods have gained significant attention as a promising approach. this study, we report on development human conditionally immortalize...

We study the mirror symmetry on singular locus of Hitchin system at two levels. First, by covering it (supports of) (BBB)-branes, corresponding to Higgs bundles reducing their structure group Levi subgroup some parabolic P, whose conjectural dual (BAA)-branes we describe. Heuristically speaking, latter are given unipotent radical P. Second, when P is a Borel subgroup, able construct family hype...

Recent animal experiments indicate a critical role for opening of the blood-brain barrier (BBB) in the pathogenesis of post-traumatic epilepsy (PTE). This study aimed to investigate the frequency, extent, and functional correlates of BBB disruption in epileptic patients following mild traumatic brain injury (TBI). Thirty-seven TBI patients were included in this study, 19 of whom suffered from P...

Most studies concerning effects of neural stimuli on the cerebral circulation have focused on changes in cerebral blood flow (CBF). The purpose of this study was to examine effects of sympathetic nerves on permeability of the blood-brain barrier (BBB) to albumin, using a quantitative method, and to relate changes in blood flow to changes in permeability of the BBB. Permeability of the BBB was e...

The transport of opioid analgesics across the blood-brain barrier (BBB) is an important determinant of their therapeutic effects. The human brain is protected by the BBB, which consists of brain capillary endothelial cells linked with tight junctions. It is well established that the polarized expression of numerous transporters and receptors at the brain capillary endothelial cells controls the...

UNLABELLED The aim of the study was to register the prevalence of late potentials (LP) in patients with chronic Chagas' heart disease (CCD) and the relationship with sustained ventricular tachycardia (SVT). 192 patients (96 males), mean age 42.9 years, with CCD were studied through a Signal Averaged ECG using time domain analysis. According to presence or absence of bundle branch block (BBB) an...